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STRINGSTRING
STAT6 STAT6 LEPRE1 LEPRE1 ITGB3 ITGB3 LEPREL1 LEPREL1 ITGA11 ITGA11 FN1 FN1 ITGAV ITGAV ITGA1 ITGA1 COL1A1 COL1A1 FIGF FIGF COL3A1 COL3A1 COL10A1 COL10A1 COL4A5 COL4A5 COL6A3 COL6A3 FLT4 FLT4 COL21A1 COL21A1 COL6A2 COL6A2 COL5A3 COL5A3 COL9A3 COL9A3 COL14A1 COL14A1 COL22A1 COL22A1 COL8A1 COL8A1 COL19A1 COL19A1 COL17A1 COL17A1 COL12A1 COL12A1 COL8A2 COL8A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
COL1A1collagen, type I, alpha 1 (1464 aa)
COL10A1collagen, type X, alpha 1; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage (680 aa)
COL21A1collagen, type XXI, alpha 1 (957 aa)
ITGAVintegrin, alpha V (1048 aa)
COL8A1collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa)
FLT4fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] (1363 aa)
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] (788 aa)
COL5A3collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa)
ITGA1integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen (1179 aa)
COL6A3collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
LEPRE1leucine proline-enriched proteoglycan (leprecan) 1 (736 aa)
COL14A1collagen, type XIV, alpha 1 (1796 aa)
FIGFc-fos induced growth factor (vascular endothelial growth factor D); Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors (354 aa)
STAT6signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling (847 aa)
COL6A2collagen, type VI, alpha 2 (1019 aa)
COL22A1collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)
COL3A1collagen, type III, alpha 1 (1466 aa)
COL8A2collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa)
COL19A1collagen, type XIX, alpha 1 (1142 aa)
LEPREL1leprecan-like 1; Shows prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types II, IV and V (By similarity) (708 aa)
COL12A1collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
ITGA11integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen (1188 aa)
COL4A5collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
COL17A1collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane (1497 aa)
COL9A3collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye (684 aa)
FN1fibronectin 1 (2477 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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