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ARHGAP15 ARHGAP15 RACGAP1 RACGAP1 SRGAP1 SRGAP1 ARHGAP39 ARHGAP39 ARHGAP23 ARHGAP23 DEPDC1B DEPDC1B CHN2 CHN2 BCR BCR ARHGDIB ARHGDIB ARHGAP44 ARHGAP44 DLC1 DLC1 RHOT1 RHOT1 RAC2 RAC2 RHOT2 RHOT2 ARHGDIG ARHGDIG ARHGAP1 ARHGAP1 SYDE1 SYDE1 KALRN KALRN ARHGAP40 ARHGAP40 MYO9B MYO9B ARHGAP31 ARHGAP31 ARHGAP8 ARHGAP8 OCRL OCRL ARHGAP12 ARHGAP12 STARD8 STARD8 CHN1 CHN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
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ARHGDIGRho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (225 aa)
CHN2chimerin 2; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors (468 aa)
ARHGDIBRho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (201 aa)
KALRNkalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (192 aa)
ARHGAP31Rho GTPase activating protein 31; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration (1444 aa)
DEPDC1BDEP domain containing 1B (529 aa)
DLC1deleted in liver cancer 1 (1528 aa)
ARHGAP15Rho GTPase activating protein 15 (475 aa)
BCRbreakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (1271 aa)
RACGAP1Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
ARHGAP1Rho GTPase activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (439 aa)
RHOT2ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa)
SYDE1synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (735 aa)
ARHGAP12Rho GTPase activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (846 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (1085 aa)
RHOT1ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) (691 aa)
OCRLoculocerebrorenal syndrome of Lowe (901 aa)
ARHGAP40Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (622 aa)
STARD8StAR-related lipid transfer (START) domain containing 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1 (1103 aa)
ARHGAP39Rho GTPase activating protein 39 (1114 aa)
ARHGAP44Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 (818 aa)
ARHGAP8Rho GTPase activating protein 8 (555 aa)
MYO9Bmyosin IXB; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho (2022 aa)
CHN1chimerin 1; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (459 aa)
ARHGAP23Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1491 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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