Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | UTP18 | UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa) | ||
 | BYSL | bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa) | ||
 | RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae); Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA (259 aa) | ||
 | DDX49 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 (483 aa) | ||
 | RPS16 | ribosomal protein S16 (146 aa) | ||
 | NOL11 | nucleolar protein 11 (719 aa) | ||
 | UTP3 | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) (479 aa) | ||
 | RPS27A | ribosomal protein S27a (156 aa) | ||
 | RPP14 | ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (124 aa) | ||
 | RPS23 | ribosomal protein S23 (143 aa) | ||
 | RPP25 | ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA (199 aa) | ||
 | RRP7A | ribosomal RNA processing 7 homolog A (S. cerevisiae) (280 aa) | ||
 | RPS27L | ribosomal protein S27-like (84 aa) | ||
 | RPS2 | ribosomal protein S2 (293 aa) | ||
 | RPSA | ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. A [...] (295 aa) | ||
 | RPS10 | ribosomal protein S10; Component of the 40S ribosomal subunit (165 aa) | ||
 | XRN2 | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription (950 aa) | ||
 | RPP40 | ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa) | ||
 | RPS29 | ribosomal protein S29 (67 aa) | ||
 | RPP30 | ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa) | ||
 | RPP21 | ribonuclease P/MRP 21kDa subunit (162 aa) | ||
 | DIEXF | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) (756 aa) | ||
 | UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast); Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity) (766 aa) | ||
 | RPS20 | ribosomal protein S20 (142 aa) | ||
 | RPS25 | ribosomal protein S25 (125 aa) | ||
 | RPS19 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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