| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CACNA1D | CACNA1F | ENSP00000288139 | ENSP00000365441 | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | calcium channel, voltage-dependent, L type, alpha 1F subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | 0.902 |
| CACNA1F | CACNA1D | ENSP00000365441 | ENSP00000288139 | calcium channel, voltage-dependent, L type, alpha 1F subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | 0.902 |
| CNGB1 | EYS | ENSP00000251102 | ENSP00000424243 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | eyes shut homolog (Drosophila) | 0.440 |
| CNGB1 | PRPH2 | ENSP00000251102 | ENSP00000230381 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.739 |
| EYS | CNGB1 | ENSP00000424243 | ENSP00000251102 | eyes shut homolog (Drosophila) | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.440 |
| EYS | MERTK | ENSP00000424243 | ENSP00000295408 | eyes shut homolog (Drosophila) | c-mer proto-oncogene tyrosine kinase; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosph [...] | 0.427 |
| GRAP2 | PRPH2 | ENSP00000339186 | ENSP00000230381 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.576 |
| HMCN1 | RAX2 | ENSP00000271588 | ENSP00000450687 | hemicentin 1 | retina and anterior neural fold homeobox 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter | 0.439 |
| MERTK | EYS | ENSP00000295408 | ENSP00000424243 | c-mer proto-oncogene tyrosine kinase; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosph [...] | eyes shut homolog (Drosophila) | 0.427 |
| PRPH | PRPH2 | ENSP00000257860 | ENSP00000230381 | peripherin; Class-III neuronal intermediate filament protein | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.616 |
| PRPH2 | CNGB1 | ENSP00000230381 | ENSP00000251102 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.739 |
| PRPH2 | GRAP2 | ENSP00000230381 | ENSP00000339186 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.576 |
| PRPH2 | PRPH | ENSP00000230381 | ENSP00000257860 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | peripherin; Class-III neuronal intermediate filament protein | 0.616 |
| PRPH2 | ROM1 | ENSP00000230381 | ENSP00000278833 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | retinal outer segment membrane protein 1; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.628 |
| RAX2 | HMCN1 | ENSP00000450687 | ENSP00000271588 | retina and anterior neural fold homeobox 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter | hemicentin 1 | 0.439 |
| ROM1 | PRPH2 | ENSP00000278833 | ENSP00000230381 | retinal outer segment membrane protein 1; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.628 |
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