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ARFGAP1 ARFGAP1 RAB6A RAB6A UBB UBB CNOT1 CNOT1 GCN1L1 GCN1L1 UBE2G2 UBE2G2 RAB6B RAB6B ELAVL1 ELAVL1 UBC UBC ATP10D ATP10D PIKFYVE PIKFYVE ATP8A1 ATP8A1 ATP11A ATP11A DNAJC3 DNAJC3 ATP8B2 ATP8B2 ATP11C ATP11C ATP10A ATP10A ATP11B ATP11B TMEM30A TMEM30A PEMT PEMT ATP8B1 ATP8B1 RAB41 RAB41 ATP8A2 ATP8A2 RAB6C RAB6C ATP8B4 ATP8B4 ATP10B ATP10B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TMEM30Atransmembrane protein 30A (361 aa)
PEMTphosphatidylethanolamine N-methyltransferase (236 aa)
PIKFYVEphosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes (2098 aa)
ATP10DATPase, class V, type 10D (1426 aa)
RAB41RAB41, member RAS oncogene family (221 aa)
ATP11AATPase, class VI, type 11A (1134 aa)
ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both (1251 aa)
ATP8B4ATPase, class I, type 8B, member 4 (1192 aa)
RAB6BRAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa)
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
UBBubiquitin B (229 aa)
RAB6ARAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
ATP10BATPase, class V, type 10B (1461 aa)
ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (414 aa)
CNOT1CCR4-NOT transcription complex, subunit 1 (2376 aa)
ATP11BATPase, class VI, type 11B (1177 aa)
ATP11CATPase, class VI, type 11C (1132 aa)
UBE2G2ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa)
UBCubiquitin C (685 aa)
ATP10AATPase, class V, type 10A (1499 aa)
ATP8B2ATPase, aminophospholipid transporter, class I, type 8B, member 2 (1223 aa)
DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (504 aa)
ATP8A2ATPase, aminophospholipid transporter, class I, type 8A, member 2 (1188 aa)
ATP8A1ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles (1164 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
RAB6CRAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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