node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NKX2-2 | POU3F2 | ENSP00000366347 | ENSP00000329170 | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | 0.405 |
NKX2-2 | POU3F3 | ENSP00000366347 | ENSP00000355001 | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.510 |
NKX2-2 | POU3F4 | ENSP00000366347 | ENSP00000362296 | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.568 |
POU3F1 | POU3F3 | ENSP00000362103 | ENSP00000355001 | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.749 |
POU3F1 | POU3F4 | ENSP00000362103 | ENSP00000362296 | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.585 |
POU3F1 | POU4F3 | ENSP00000362103 | ENSP00000230732 | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.491 |
POU3F2 | NKX2-2 | ENSP00000329170 | ENSP00000366347 | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | 0.405 |
POU3F2 | POU3F4 | ENSP00000329170 | ENSP00000362296 | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.577 |
POU3F2 | POU4F3 | ENSP00000329170 | ENSP00000230732 | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.498 |
POU3F3 | NKX2-2 | ENSP00000355001 | ENSP00000366347 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | 0.510 |
POU3F3 | POU3F1 | ENSP00000355001 | ENSP00000362103 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.749 |
POU3F3 | POU3F4 | ENSP00000355001 | ENSP00000362296 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | 0.580 |
POU3F3 | POU4F3 | ENSP00000355001 | ENSP00000230732 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.498 |
POU3F4 | NKX2-2 | ENSP00000362296 | ENSP00000366347 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) | 0.568 |
POU3F4 | POU3F1 | ENSP00000362296 | ENSP00000362103 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.585 |
POU3F4 | POU3F2 | ENSP00000362296 | ENSP00000329170 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | 0.577 |
POU3F4 | POU3F3 | ENSP00000362296 | ENSP00000355001 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) | 0.580 |
POU3F4 | POU4F3 | ENSP00000362296 | ENSP00000230732 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.507 |
POU4F3 | POU3F1 | ENSP00000230732 | ENSP00000362103 | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis | 0.491 |
POU4F3 | POU3F2 | ENSP00000230732 | ENSP00000329170 | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) | 0.498 |