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POU4F3 | POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons (338 aa) | |||
NKX2-8 | NK2 homeobox 8 (239 aa) | |||
POU5F1 | POU class 5 homeobox 1 (360 aa) | |||
POU2F3 | POU class 2 homeobox 3; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Regulated the expression of a number of genes such as SPRR2A or placental lactogen (436 aa) | |||
HESX1 | HESX homeobox 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5’-AGCTTGAGTCTAATTGAATTAACTGTAC-3’. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity) (185 aa) | |||
OTP | orthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa) | |||
NKX2-6 | NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity) (301 aa) | |||
NKX2-5 | NK2 homeobox 5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity) (324 aa) | |||
POU3F2 | POU class 3 homeobox 2; Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity) (443 aa) | |||
POU6F1 | POU class 6 homeobox 1; Transcription factor that binds preferentially to a variant of the octamer motif (5’-ATGATAAT-3’) (By similarity) (301 aa) | |||
ALX4 | ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development (411 aa) | |||
NKX2-3 | NK2 homeobox 3; Transcription factor (By similarity) (364 aa) | |||
POU1F1 | POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5’- TAAAT-3’ (317 aa) | |||
NKX2-4 | NK2 homeobox 4; Probable transcription factor (354 aa) | |||
NKX2-1 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis (401 aa) | |||
POU3F3 | POU class 3 homeobox 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5’-ATTTGCAT-3’) (By similarity) (500 aa) | |||
POU2F1 | POU class 2 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes (766 aa) | |||
POU3F1 | POU class 3 homeobox 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis (451 aa) | |||
POU3F4 | POU class 3 homeobox 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain (361 aa) | |||
NKX2-2 | NK2 homeobox 2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) (273 aa) | |||
NKX3-1 | NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells (234 aa) | |||
NKX3-2 | NK3 homeobox 2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity) (333 aa) | |||
POU5F1B | POU class 5 homeobox 1B; Shows weak transcriptional activator activity (359 aa) | |||
POU6F2 | POU class 6 homeobox 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5’-ATGCAAAT-3’. Isoform 1 does not bind DNA (691 aa) | |||
POU2F2 | POU class 2 homeobox 2; Transcription factor that specifically binds to the octamer motif (5’-ATTTGCAT-3’). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter (479 aa) | |||
POU5F2 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) (328 aa) |