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ARHGEF1 ARHGEF1 SRGAP1 SRGAP1 ARHGAP39 ARHGAP39 BCR BCR ARHGAP23 ARHGAP23 ARHGAP28 ARHGAP28 ROCK2 ROCK2 ARHGAP44 ARHGAP44 ARHGAP1 ARHGAP1 ROCK1 ROCK1 RACGAP1 RACGAP1 ECT2 ECT2 OCRL OCRL RHOT2 RHOT2 KALRN KALRN RHOT1 RHOT1 ARHGAP40 ARHGAP40 CHN2 CHN2 STARD8 STARD8 DLC1 DLC1 ARHGAP15 ARHGAP15 SYDE1 SYDE1 ARHGAP31 ARHGAP31 ARHGAP8 ARHGAP8 CHN1 CHN1 ARHGAP12 ARHGAP12
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
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protein homology
Your Input:
CHN2chimerin 2; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors (468 aa)
ECT2epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] (883 aa)
KALRNkalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
ARHGAP31Rho GTPase activating protein 31; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration (1444 aa)
DLC1deleted in liver cancer 1 (1528 aa)
ARHGAP15Rho GTPase activating protein 15 (475 aa)
BCRbreakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (1271 aa)
RACGAP1Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
ARHGAP1Rho GTPase activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (439 aa)
ARHGAP28Rho GTPase activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (570 aa)
ROCK2Rho-associated, coiled-coil containing protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MA [...] (1388 aa)
RHOT2ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa)
ARHGEF1Rho guanine nucleotide exchange factor (GEF) 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation (927 aa)
SYDE1synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (735 aa)
ARHGAP12Rho GTPase activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (846 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (1085 aa)
RHOT1ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) (691 aa)
OCRLoculocerebrorenal syndrome of Lowe (901 aa)
ARHGAP40Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (622 aa)
STARD8StAR-related lipid transfer (START) domain containing 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1 (1103 aa)
ARHGAP39Rho GTPase activating protein 39 (1114 aa)
ARHGAP44Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 (818 aa)
ARHGAP8Rho GTPase activating protein 8 (555 aa)
ROCK1Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...] (1354 aa)
CHN1chimerin 1; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (459 aa)
ARHGAP23Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1491 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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