Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
||||
 | RPL19 | ribosomal protein L19 (196 aa) | ||
 | ISL1 | ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa) | ||
 | SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (169 aa) | ||
 | RPS4Y1 | ribosomal protein S4, Y-linked 1 (263 aa) | ||
 | RPL27 | ribosomal protein L27 (136 aa) | ||
 | SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (226 aa) | ||
 | SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein); Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa) | ||
 | RPS11 | ribosomal protein S11 (158 aa) | ||
 | RPL29 | ribosomal protein L29 (159 aa) | ||
 | RPL38 | ribosomal protein L38 (70 aa) | ||
 | MBOAT4 | membrane bound O-acyltransferase domain containing 4; Mediates the octanoylation of ghrelin at ’Ser-3’. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid (435 aa) | ||
 | SEC62 | SEC62 homolog (S. cerevisiae); Required for preprotein translocation (By similarity) (399 aa) | ||
 | SEC61G | Sec61 gamma subunit; Necessary for protein translocation in the endoplasmic reticulum (By similarity) (68 aa) | ||
 | SRP72 | signal recognition particle 72kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (671 aa) | ||
 | RPL14 | ribosomal protein L14 (215 aa) | ||
 | RPS10 | ribosomal protein S10; Component of the 40S ribosomal subunit (165 aa) | ||
 | RPL12 | ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) (165 aa) | ||
 | RPL39 | ribosomal protein L39 (51 aa) | ||
 | RPS27 | ribosomal protein S27 (84 aa) | ||
 | RPL11 | ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa) | ||
 | DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (456 aa) | ||
 | RPS6 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (249 aa) | ||
 | CDX2 | caudal type homeobox 2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine (313 aa) | ||
 | GCG | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life (180 aa) | ||
 | SRPRB | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) (271 aa) | ||
 | SRP19 | signal recognition particle 19kDa; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (144 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
