node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN1 | F13A1 | ENSP00000377941 | ENSP00000264870 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | 0.903 |
ACTN1 | PF4 | ENSP00000377941 | ENSP00000296029 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | 0.901 |
ACTN1 | PLEK | ENSP00000377941 | ENSP00000234313 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | pleckstrin; Major protein kinase C substrate of platelets | 0.653 |
F13A1 | ACTN1 | ENSP00000264870 | ENSP00000377941 | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.903 |
F13A1 | PF4 | ENSP00000264870 | ENSP00000296029 | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | 0.908 |
F13A1 | PLEK | ENSP00000264870 | ENSP00000234313 | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | pleckstrin; Major protein kinase C substrate of platelets | 0.580 |
HSD17B4 | PLEK | ENSP00000420914 | ENSP00000234313 | hydroxysteroid (17-beta) dehydrogenase 4; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids | pleckstrin; Major protein kinase C substrate of platelets | 0.572 |
INPP5A | PLEK | ENSP00000357583 | ENSP00000234313 | inositol polyphosphate-5-phosphatase, 40kDa; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction | pleckstrin; Major protein kinase C substrate of platelets | 0.613 |
MSN | PLEK | ENSP00000353408 | ENSP00000234313 | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | pleckstrin; Major protein kinase C substrate of platelets | 0.804 |
PF4 | ACTN1 | ENSP00000296029 | ENSP00000377941 | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.901 |
PF4 | F13A1 | ENSP00000296029 | ENSP00000264870 | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | 0.908 |
PF4 | PLEK | ENSP00000296029 | ENSP00000234313 | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | pleckstrin; Major protein kinase C substrate of platelets | 0.598 |
PF4 | THBS1 | ENSP00000296029 | ENSP00000260356 | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.581 |
PLEK | ACTN1 | ENSP00000234313 | ENSP00000377941 | pleckstrin; Major protein kinase C substrate of platelets | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.653 |
PLEK | F13A1 | ENSP00000234313 | ENSP00000264870 | pleckstrin; Major protein kinase C substrate of platelets | coagulation factor XIII, A1 polypeptide; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin | 0.580 |
PLEK | HSD17B4 | ENSP00000234313 | ENSP00000420914 | pleckstrin; Major protein kinase C substrate of platelets | hydroxysteroid (17-beta) dehydrogenase 4; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids | 0.572 |
PLEK | INPP5A | ENSP00000234313 | ENSP00000357583 | pleckstrin; Major protein kinase C substrate of platelets | inositol polyphosphate-5-phosphatase, 40kDa; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction | 0.613 |
PLEK | MSN | ENSP00000234313 | ENSP00000353408 | pleckstrin; Major protein kinase C substrate of platelets | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | 0.804 |
PLEK | PF4 | ENSP00000234313 | ENSP00000296029 | pleckstrin; Major protein kinase C substrate of platelets | platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form | 0.598 |
PLEK | RDX | ENSP00000234313 | ENSP00000342830 | pleckstrin; Major protein kinase C substrate of platelets | radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane | 0.805 |