5 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	BCL9	B-cell CLL/lymphoma 9 (1426 aa)
	PYGO1	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway (419 aa)
	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] (781 aa)
	PYGO2	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway (406 aa)
	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box) (602 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9	CTNNB1	ENSP00000234739	ENSP00000344456	B-cell CLL/lymphoma 9	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	0.993
BCL9	PYGO1	ENSP00000234739	ENSP00000302327	B-cell CLL/lymphoma 9	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	0.981
BCL9	PYGO2	ENSP00000234739	ENSP00000357442	B-cell CLL/lymphoma 9	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	0.773
BCL9	TCF7L2	ENSP00000234739	ENSP00000444972	B-cell CLL/lymphoma 9	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.909
CTNNB1	BCL9	ENSP00000344456	ENSP00000234739	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	B-cell CLL/lymphoma 9	0.993
CTNNB1	PYGO1	ENSP00000344456	ENSP00000302327	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	0.981
CTNNB1	PYGO2	ENSP00000344456	ENSP00000357442	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	0.942
CTNNB1	TCF7L2	ENSP00000344456	ENSP00000444972	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.999
PYGO1	BCL9	ENSP00000302327	ENSP00000234739	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	B-cell CLL/lymphoma 9	0.981
PYGO1	CTNNB1	ENSP00000302327	ENSP00000344456	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	0.981
PYGO1	PYGO2	ENSP00000302327	ENSP00000357442	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	0.913
PYGO1	TCF7L2	ENSP00000302327	ENSP00000444972	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.938
PYGO2	BCL9	ENSP00000357442	ENSP00000234739	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	B-cell CLL/lymphoma 9	0.773
PYGO2	CTNNB1	ENSP00000357442	ENSP00000344456	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	0.942
PYGO2	PYGO1	ENSP00000357442	ENSP00000302327	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	0.913
PYGO2	TCF7L2	ENSP00000357442	ENSP00000444972	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.900
TCF7L2	BCL9	ENSP00000444972	ENSP00000234739	transcription factor 7-like 2 (T-cell specific, HMG-box)	B-cell CLL/lymphoma 9	0.909
TCF7L2	CTNNB1	ENSP00000444972	ENSP00000344456	transcription factor 7-like 2 (T-cell specific, HMG-box)	catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...]	0.999
TCF7L2	PYGO1	ENSP00000444972	ENSP00000302327	transcription factor 7-like 2 (T-cell specific, HMG-box)	pygopus homolog 1 (Drosophila); Involved in signal transduction through the Wnt pathway	0.938
TCF7L2	PYGO2	ENSP00000444972	ENSP00000357442	transcription factor 7-like 2 (T-cell specific, HMG-box)	pygopus homolog 2 (Drosophila); Involved in signal transduction through the Wnt pathway	0.900

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