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STRINGSTRING
RBP1 RBP1 STRA6 STRA6 RBP4 RBP4 HNF4A HNF4A CEBPD CEBPD CEBPB CEBPB CEBPA CEBPA TTR TTR APOA4 APOA4 CALCA CALCA PRL PRL FGA FGA LYZ LYZ SEMG1 SEMG1 SNCA SNCA GSN GSN ODAM ODAM CST3 CST3 ITM2B ITM2B LTF LTF SAA1 SAA1 NPPA NPPA TGFBI TGFBI IAPP IAPP B2M B2M APCS APCS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LTFlactotransferrin (710 aa)
RBP1retinol binding protein 1, cellular; Intracellular transport of retinol (197 aa)
TTRtransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (147 aa)
IAPPislet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism (89 aa)
APCSamyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin (223 aa)
LYZlysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents (148 aa)
PRLprolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
CEBPBCCAAT/enhancer binding protein (C/EBP), beta; Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5’-T[TG]NNGNAA[TG]-3’. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proli [...] (345 aa)
FGAfibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (866 aa)
HNF4Ahepatocyte nuclear factor 4, alpha (474 aa)
CALCAcalcitonin-related polypeptide alpha; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones (141 aa)
SNCAsynuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation (140 aa)
SAA1serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) (122 aa)
APOA4apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (396 aa)
RBP4retinol binding protein 4, plasma; Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli (201 aa)
SEMG1semenogelin I (462 aa)
GSNgelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (782 aa)
NPPAnatriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (151 aa)
CST3cystatin C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity (146 aa)
ITM2Bintegral membrane protein 2B; Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (266 aa)
ODAModontogenic, ameloblast asssociated; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process (279 aa)
CEBPDCCAAT/enhancer binding protein (C/EBP), delta; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages (269 aa)
TGFBItransforming growth factor, beta-induced, 68kDa (683 aa)
CEBPACCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (358 aa)
B2Mbeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)
STRA6stimulated by retinoic acid 6 homolog (mouse) (706 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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