node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMY1C | PYGB | ENSP00000359096 | ENSP00000216962 | amylase, alpha 1C (salivary) | phosphorylase, glycogen; brain; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) | 0.551 |
EPM2A | GYG1 | ENSP00000356489 | ENSP00000340736 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.900 |
EPM2A | GYG2 | ENSP00000356489 | ENSP00000370555 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.900 |
EPM2A | GYS1 | ENSP00000356489 | ENSP00000317904 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.988 |
EPM2A | GYS2 | ENSP00000356489 | ENSP00000261195 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | glycogen synthase 2 (liver); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.964 |
EPM2A | PPP1R3C | ENSP00000356489 | ENSP00000238994 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.994 |
EPM2A | PPP1R3D | ENSP00000356489 | ENSP00000360035 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | protein phosphatase 1, regulatory subunit 3D; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis | 0.618 |
GABARAPL1 | STBD1 | ENSP00000266458 | ENSP00000237642 | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | starch binding domain 1; May have the capability to bind to carbohydrates (Potential) | 0.722 |
GYG1 | EPM2A | ENSP00000340736 | ENSP00000356489 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.900 |
GYG1 | GYG2 | ENSP00000340736 | ENSP00000370555 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.957 |
GYG1 | GYS1 | ENSP00000340736 | ENSP00000317904 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.998 |
GYG1 | GYS2 | ENSP00000340736 | ENSP00000261195 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogen synthase 2 (liver); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.988 |
GYG1 | PPP1R3C | ENSP00000340736 | ENSP00000238994 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.933 |
GYG1 | PYGB | ENSP00000340736 | ENSP00000216962 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | phosphorylase, glycogen; brain; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) | 0.925 |
GYG2 | EPM2A | ENSP00000370555 | ENSP00000356489 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.900 |
GYG2 | GYG1 | ENSP00000370555 | ENSP00000340736 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.957 |
GYG2 | GYS1 | ENSP00000370555 | ENSP00000317904 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.996 |
GYG2 | GYS2 | ENSP00000370555 | ENSP00000261195 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogen synthase 2 (liver); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | 0.981 |
GYG2 | PPP1R3C | ENSP00000370555 | ENSP00000238994 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.911 |
GYS1 | EPM2A | ENSP00000317904 | ENSP00000356489 | glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.988 |