node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK19 | FKBP15 | ENSP00000357907 | ENSP00000238256 | cyclin-dependent kinase 19 | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | 0.644 |
FAM21C | FKBP15 | ENSP00000363482 | ENSP00000238256 | family with sequence similarity 21, member C | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | 0.499 |
FAM21C | KIAA0196 | ENSP00000363482 | ENSP00000318016 | family with sequence similarity 21, member C | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | 0.710 |
FAM21C | KIAA1033 | ENSP00000363482 | ENSP00000328062 | family with sequence similarity 21, member C | KIAA1033; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) | 0.602 |
FKBP15 | CDK19 | ENSP00000238256 | ENSP00000357907 | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | cyclin-dependent kinase 19 | 0.644 |
FKBP15 | FAM21C | ENSP00000238256 | ENSP00000363482 | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | family with sequence similarity 21, member C | 0.499 |
FKBP15 | UBC | ENSP00000238256 | ENSP00000344818 | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | ubiquitin C | 0.620 |
KIAA0196 | FAM21C | ENSP00000318016 | ENSP00000363482 | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | family with sequence similarity 21, member C | 0.710 |
KIAA0196 | KIAA1033 | ENSP00000318016 | ENSP00000328062 | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | KIAA1033; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) | 0.999 |
KIAA0196 | UBC | ENSP00000318016 | ENSP00000344818 | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | ubiquitin C | 0.891 |
KIAA0196 | VPS26A | ENSP00000318016 | ENSP00000263559 | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.436 |
KIAA1033 | FAM21C | ENSP00000328062 | ENSP00000363482 | KIAA1033; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) | family with sequence similarity 21, member C | 0.602 |
KIAA1033 | KIAA0196 | ENSP00000328062 | ENSP00000318016 | KIAA1033; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) | KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | 0.999 |
KIAA1033 | UBC | ENSP00000328062 | ENSP00000344818 | KIAA1033; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) | ubiquitin C | 0.834 |
MB21D1 | UBC | ENSP00000359339 | ENSP00000344818 | Mab-21 domain containing 1; Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production | ubiquitin C | 0.735 |
SNAP29 | UBC | ENSP00000215730 | ENSP00000344818 | synaptosomal-associated protein, 29kDa; SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps | ubiquitin C | 0.722 |
SSFA2 | UBC | ENSP00000388731 | ENSP00000344818 | sperm specific antigen 2 | ubiquitin C | 0.721 |
STRN3 | UBC | ENSP00000350071 | ENSP00000344818 | striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | ubiquitin C | 0.733 |
TTBK2 | UBC | ENSP00000267890 | ENSP00000344818 | tau tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | ubiquitin C | 0.597 |
UBC | FKBP15 | ENSP00000344818 | ENSP00000238256 | ubiquitin C | FK506 binding protein 15, 133kDa; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement | 0.620 |