node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD3 | TP53I3 | ENSP00000359233 | ENSP00000238721 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.644 |
EI24 | TP53I3 | ENSP00000278903 | ENSP00000238721 | etoposide induced 2.4 mRNA; Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity) | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.846 |
FAM3C | TP53I3 | ENSP00000353025 | ENSP00000238721 | family with sequence similarity 3, member C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.644 |
FUBP1 | MRPL42 | ENSP00000359804 | ENSP00000447547 | far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | mitochondrial ribosomal protein L42 | 0.644 |
FUBP1 | TP53I3 | ENSP00000359804 | ENSP00000238721 | far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.644 |
ICT1 | MRPL10 | ENSP00000301585 | ENSP00000290208 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L10 | 0.928 |
ICT1 | MRPL12 | ENSP00000301585 | ENSP00000333837 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L12 | 0.987 |
ICT1 | MRPL13 | ENSP00000301585 | ENSP00000306548 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L13 | 0.903 |
ICT1 | MRPL23 | ENSP00000301585 | ENSP00000370930 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L23 | 0.951 |
ICT1 | MRPL3 | ENSP00000301585 | ENSP00000264995 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L3 | 0.986 |
ICT1 | MRPL42 | ENSP00000301585 | ENSP00000447547 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L42 | 0.903 |
ICT1 | MRPL51 | ENSP00000301585 | ENSP00000229238 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L51 | 0.934 |
ICT1 | MRPL52 | ENSP00000301585 | ENSP00000347277 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L52 | 0.910 |
ICT1 | MRPL55 | ENSP00000301585 | ENSP00000355692 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L55 | 0.938 |
ICT1 | MRPS28 | ENSP00000301585 | ENSP00000276585 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein S28 | 0.699 |
ICT1 | MRPS9 | ENSP00000301585 | ENSP00000258455 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein S9 | 0.693 |
ICT1 | TP53I3 | ENSP00000301585 | ENSP00000238721 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.922 |
MRPL10 | ICT1 | ENSP00000290208 | ENSP00000301585 | mitochondrial ribosomal protein L10 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.928 |
MRPL10 | MRPL12 | ENSP00000290208 | ENSP00000333837 | mitochondrial ribosomal protein L10 | mitochondrial ribosomal protein L12 | 0.974 |
MRPL10 | MRPL13 | ENSP00000290208 | ENSP00000306548 | mitochondrial ribosomal protein L10 | mitochondrial ribosomal protein L13 | 0.936 |