node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C14orf166 | DDX1 | ENSP00000261700 | ENSP00000233084 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.999 |
C14orf166 | FAM98A | ENSP00000261700 | ENSP00000238823 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | family with sequence similarity 98, member A | 0.929 |
C14orf166 | UBC | ENSP00000261700 | ENSP00000344818 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | ubiquitin C | 0.944 |
CUL5 | UBC | ENSP00000376808 | ENSP00000344818 | cullin 5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by [...] | ubiquitin C | 0.998 |
DDX1 | C14orf166 | ENSP00000233084 | ENSP00000261700 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | 0.999 |
DDX1 | FAM98A | ENSP00000233084 | ENSP00000238823 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | family with sequence similarity 98, member A | 0.823 |
DDX1 | UBC | ENSP00000233084 | ENSP00000344818 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | ubiquitin C | 0.927 |
FAM98A | C14orf166 | ENSP00000238823 | ENSP00000261700 | family with sequence similarity 98, member A | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | 0.929 |
FAM98A | DDX1 | ENSP00000238823 | ENSP00000233084 | family with sequence similarity 98, member A | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.823 |
FAM98A | UBC | ENSP00000238823 | ENSP00000344818 | family with sequence similarity 98, member A | ubiquitin C | 0.924 |
FUS | TARDBP | ENSP00000254108 | ENSP00000240185 | fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity | TAR DNA binding protein | 0.948 |
FUS | UBC | ENSP00000254108 | ENSP00000344818 | fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity | ubiquitin C | 0.925 |
MEX3C | UBC | ENSP00000385610 | ENSP00000344818 | mex-3 homolog C (C. elegans); E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3’ UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation | ubiquitin C | 0.483 |
TARDBP | FUS | ENSP00000240185 | ENSP00000254108 | TAR DNA binding protein | fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity | 0.948 |
TARDBP | UBC | ENSP00000240185 | ENSP00000344818 | TAR DNA binding protein | ubiquitin C | 0.999 |
UBC | C14orf166 | ENSP00000344818 | ENSP00000261700 | ubiquitin C | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | 0.944 |
UBC | CUL5 | ENSP00000344818 | ENSP00000376808 | ubiquitin C | cullin 5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by [...] | 0.998 |
UBC | DDX1 | ENSP00000344818 | ENSP00000233084 | ubiquitin C | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.927 |
UBC | FAM98A | ENSP00000344818 | ENSP00000238823 | ubiquitin C | family with sequence similarity 98, member A | 0.924 |
UBC | FUS | ENSP00000344818 | ENSP00000254108 | ubiquitin C | fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity | 0.925 |