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STRINGSTRING
UPRT UPRT PTPN20A PTPN20A PTPN3 PTPN3 UCKL1 UCKL1 PCDHB10 PCDHB10 PKP1 PKP1 PTPN2 PTPN2 PTPRT PTPRT PTPRK PTPRK PTPRF PTPRF PTPRE PTPRE PTPRS PTPRS ARVCF ARVCF PKP2 PKP2 CTNNB1 CTNNB1 JUP JUP PTPRQ PTPRQ PTPN18 PTPN18 PKP4 PKP4 PTPRZ1 PTPRZ1 CTNND1 CTNND1 PCDHB15 PCDHB15 CTNND2 CTNND2 PTPN7 PTPN7 TTF2 TTF2 PKP3 PKP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PKP2plakophilin 2; May play a role in junctional plaques (881 aa)
PTPN18protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues (460 aa)
PCDHB15protocadherin beta 15; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity) (787 aa)
PCDHB10protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity) (800 aa)
PTPREprotein tyrosine phosphatase, receptor type, E; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity) (700 aa)
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions (962 aa)
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (747 aa)
PTPRQprotein tyrosine phosphatase, receptor type, Q; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in viv [...] (2295 aa)
CTNND2catenin (cadherin-associated protein), delta 2 (1225 aa)
PTPN7protein tyrosine phosphatase, non-receptor type 7; Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction (465 aa)
JUPjunction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
PTPN2protein tyrosine phosphatase, non-receptor type 2 (415 aa)
PKP3plakophilin 3; May play a role in junctional plaques (797 aa)
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] (781 aa)
UCKL1uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation (548 aa)
PTPRSprotein tyrosine phosphatase, receptor type, S; Interacts with LAR-interacting protein LIP.1 (1948 aa)
PTPRFprotein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (1907 aa)
PTPRKprotein tyrosine phosphatase, receptor type, K; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa (1446 aa)
TTF2transcription termination factor, RNA polymerase II; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (1162 aa)
PTPRTprotein tyrosine phosphatase, receptor type, T (1441 aa)
UPRTuracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) (309 aa)
PTPN20Aprotein tyrosine phosphatase, non-receptor type 20A (420 aa)
PTPN3protein tyrosine phosphatase, non-receptor type 3; May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity (913 aa)
PKP4plakophilin 4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (1192 aa)
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1; May be involved in the regulation of specific developmental processes in the CNS (2315 aa)
CTNND1catenin (cadherin-associated protein), delta 1 (968 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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