node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2B2 | PDZD11 | ENSP00000324172 | ENSP00000239666 | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | PDZ domain containing 11 | 0.644 |
ATP2B2 | UBC | ENSP00000324172 | ENSP00000344818 | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | ubiquitin C | 0.905 |
ATP2B2 | YWHAE | ENSP00000324172 | ENSP00000264335 | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.629 |
ATP7A | PDZD11 | ENSP00000345728 | ENSP00000239666 | ATPase, Cu++ transporting, alpha polypeptide; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells | PDZ domain containing 11 | 0.849 |
ATP7A | UBC | ENSP00000345728 | ENSP00000344818 | ATPase, Cu++ transporting, alpha polypeptide; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells | ubiquitin C | 0.703 |
LATS2 | UBC | ENSP00000372035 | ENSP00000344818 | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | ubiquitin C | 0.625 |
LATS2 | YWHAE | ENSP00000372035 | ENSP00000264335 | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.902 |
PDZD11 | ATP2B2 | ENSP00000239666 | ENSP00000324172 | PDZ domain containing 11 | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | 0.644 |
PDZD11 | ATP7A | ENSP00000239666 | ENSP00000345728 | PDZ domain containing 11 | ATPase, Cu++ transporting, alpha polypeptide; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells | 0.849 |
PDZD11 | PLEKHA5 | ENSP00000239666 | ENSP00000347560 | PDZ domain containing 11 | pleckstrin homology domain containing, family A member 5 | 0.614 |
PDZD11 | YWHAH | ENSP00000239666 | ENSP00000248975 | PDZ domain containing 11 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 | 0.619 |
PLEKHA5 | PDZD11 | ENSP00000347560 | ENSP00000239666 | pleckstrin homology domain containing, family A member 5 | PDZ domain containing 11 | 0.614 |
SIGMAR1 | UBC | ENSP00000277010 | ENSP00000344818 | sigma non-opioid intracellular receptor 1 | ubiquitin C | 0.932 |
UBC | ATP2B2 | ENSP00000344818 | ENSP00000324172 | ubiquitin C | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | 0.905 |
UBC | ATP7A | ENSP00000344818 | ENSP00000345728 | ubiquitin C | ATPase, Cu++ transporting, alpha polypeptide; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells | 0.703 |
UBC | LATS2 | ENSP00000344818 | ENSP00000372035 | ubiquitin C | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | 0.625 |
UBC | SIGMAR1 | ENSP00000344818 | ENSP00000277010 | ubiquitin C | sigma non-opioid intracellular receptor 1 | 0.932 |
UBC | YWHAE | ENSP00000344818 | ENSP00000264335 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.996 |
UBC | YWHAH | ENSP00000344818 | ENSP00000248975 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 | 0.985 |
YWHAE | ATP2B2 | ENSP00000264335 | ENSP00000324172 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | 0.629 |