adenosylhomocysteinase-like 1

transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate

adenosylhomocysteinase-like 1

thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor

adenosylhomocysteinase-like 1

tetratricopeptide repeat domain 1

adenosylhomocysteinase-like 1

tubulin tyrosine ligase-like family, member 12

adenosylhomocysteinase-like 1

ubiquitin A-52 residue ribosomal protein fusion product 1

adenosylhomocysteinase-like 1

ubiquitin C

adenosylhomocysteinase-like 1

ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...]

adenosylhomocysteinase-like 1

ubiquitination factor E4B; Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity)

adenosylhomocysteinase-like 1

UBX domain protein 1; Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds ’Lys-6’-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol

adenosylhomocysteinase-like 1

ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage

adenosylhomocysteinase-like 1

ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1

adenosylhomocysteinase-like 1

ubiquitin specific peptidase 34

adenosylhomocysteinase-like 1

ubiquitin specific peptidase 9, X-linked; Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both ’Lys-29’- and ’Lys-33’-linked polyubiquitins chains. Specificall [...]

adenosylhomocysteinase-like 1

Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...]

adenosylhomocysteinase-like 1

zinc finger, FYVE domain containing 19

adenosylhomocysteinase-like 1

zinc finger protein 259; May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus

CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)

ubiquitin C

CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)

ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage

CDK5 regulatory subunit associated protein 3; Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity)

ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1

proteasome (prosome, macropain) subunit, beta type, 1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)

RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome