26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	MRPS10	mitochondrial ribosomal protein S10 (201 aa)
	MRPS35	mitochondrial ribosomal protein S35 (323 aa)
	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (1023 aa)
	MRPL27	mitochondrial ribosomal protein L27 (148 aa)
	MRPS2	mitochondrial ribosomal protein S2 (296 aa)
	MRPS7	mitochondrial ribosomal protein S7 (242 aa)
	MRPS9	mitochondrial ribosomal protein S9 (396 aa)
	MRPS5	mitochondrial ribosomal protein S5 (430 aa)
	MRPL49	mitochondrial ribosomal protein L49 (166 aa)
	MRPL17	mitochondrial ribosomal protein L17 (175 aa)
	MRPL13	mitochondrial ribosomal protein L13 (178 aa)
	MRPS12	mitochondrial ribosomal protein S12 (138 aa)
	MRPL46	mitochondrial ribosomal protein L46 (279 aa)
	MRPL1	mitochondrial ribosomal protein L1 (325 aa)
	MRPL43	mitochondrial ribosomal protein L43 (235 aa)
	DAP3	death associated protein 3; Involved in mediating interferon-gamma-induced cell death (398 aa)
	UBC	ubiquitin C (685 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (386 aa)
	MRPL41	mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
	MRPS16	mitochondrial ribosomal protein S16 (137 aa)
	MRPS15	mitochondrial ribosomal protein S15 (257 aa)
	METTL17	methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa)
	MRPL19	mitochondrial ribosomal protein L19 (292 aa)
	MRPS6	mitochondrial ribosomal protein S6 (125 aa)
	MRPS14	mitochondrial ribosomal protein S14 (128 aa)
	MRPL22	mitochondrial ribosomal protein L22 (206 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAP3	HIBCH	ENSP00000341692	ENSP00000352706	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	0.946
DAP3	METTL17	ENSP00000341692	ENSP00000372445	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity)	0.908
DAP3	MRPS10	ENSP00000341692	ENSP00000053468	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S10	0.966
DAP3	MRPS12	ENSP00000341692	ENSP00000308845	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S12	0.441
DAP3	MRPS15	ENSP00000341692	ENSP00000362208	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S15	0.909
DAP3	MRPS16	ENSP00000341692	ENSP00000362036	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S16	0.906
DAP3	MRPS2	ENSP00000341692	ENSP00000241600	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S2	0.973
DAP3	MRPS35	ENSP00000341692	ENSP00000081029	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S35	0.888
DAP3	MRPS5	ENSP00000341692	ENSP00000272418	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S5	0.964
DAP3	MRPS6	ENSP00000341692	ENSP00000382250	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S6	0.917
DAP3	MRPS7	ENSP00000341692	ENSP00000245539	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S7	0.734
DAP3	MRPS9	ENSP00000341692	ENSP00000258455	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	mitochondrial ribosomal protein S9	0.886
DAP3	UBC	ENSP00000341692	ENSP00000344818	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	ubiquitin C	0.820
HIBCH	DAP3	ENSP00000352706	ENSP00000341692	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	death associated protein 3; Involved in mediating interferon-gamma-induced cell death	0.946
HIBCH	METTL17	ENSP00000352706	ENSP00000372445	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity)	0.942
HIBCH	MRPS10	ENSP00000352706	ENSP00000053468	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	mitochondrial ribosomal protein S10	0.946
HIBCH	MRPS15	ENSP00000352706	ENSP00000362208	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	mitochondrial ribosomal protein S15	0.914
HIBCH	MRPS16	ENSP00000352706	ENSP00000362036	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	mitochondrial ribosomal protein S16	0.488
HIBCH	MRPS2	ENSP00000352706	ENSP00000241600	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	mitochondrial ribosomal protein S2	0.950
HIBCH	MRPS35	ENSP00000352706	ENSP00000081029	3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA	mitochondrial ribosomal protein S35	0.944

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