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HLA-DRB5 HLA-DRB5 CD74 CD74 KIF4A KIF4A GPLD1 GPLD1 KDELR1 KDELR1 HLA-DRB1 HLA-DRB1 KIF4B KIF4B ARHGAP1 ARHGAP1 KDELR2 KDELR2 ARF1 ARF1 SH3GL2 SH3GL2 AP2A2 AP2A2 CLTA CLTA NCF2 NCF2 RPS6KA4 RPS6KA4 CLTB CLTB CHN1 CHN1 COPA COPA RPS6KA3 RPS6KA3 RPS6KA5 RPS6KA5 CLTC CLTC RPS6KA1 RPS6KA1 NTRK1 NTRK1 GBF1 GBF1 USO1 USO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CD74CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa)
GPLD1glycosylphosphatidylinositol specific phospholipase D1 (840 aa)
CLTAclathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (248 aa)
KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (212 aa)
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA trans [...] (802 aa)
CLTCclathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (1675 aa)
ARF1ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] (181 aa)
CLTBclathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (229 aa)
ARHGAP1Rho GTPase activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (439 aa)
KDELR1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (212 aa)
RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 4; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in [...] (772 aa)
HLA-DRB1major histocompatibility complex, class II, DR beta 1 (266 aa)
NCF2neutrophil cytosolic factor 2 (526 aa)
COPAcoatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] (1233 aa)
GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) (1859 aa)
KIF4Akinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (1232 aa)
HLA-DRB5major histocompatibility complex, class II, DR beta 5 (266 aa)
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at ’Ser-10’, which results [...] (740 aa)
SH3GL2SH3-domain GRB2-like 2; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (352 aa)
CHN1chimerin 1; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (459 aa)
KIF4Bkinesin family member 4B; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity) (1234 aa)
AP2A2adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (939 aa)
NTRK1neurotrophic tyrosine kinase, receptor, type 1 (796 aa)
RPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 1 (744 aa)
USO1USO1 vesicle docking protein homolog (yeast); General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity) (971 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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