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ACSM5 ACSM5 ACSM3 ACSM3 ACSM4 ACSM4 ACSM2B ACSM2B ACSM1 ACSM1 DBT DBT EHHADH EHHADH ACAA2 ACAA2 HADHA HADHA ACAA1 ACAA1 ACSM2A ACSM2A C6orf174 C6orf174 ACAT2 ACAT2 GCDH GCDH ACADS ACADS ACAT1 ACAT1 ECHS1 ECHS1 HADHB HADHB SOGA1 SOGA1 ZNF830 ZNF830 SEPHS2 SEPHS2 HIVEP1 HIVEP1 SEPHS1 SEPHS1 SOGA2 SOGA2 KPNA2 KPNA2 SOGA3 SOGA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACSM2Aacyl-CoA synthetase medium-chain family member 2A; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) (577 aa)
GCDHglutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive (438 aa)
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
SOGA1suppressor of glucose, autophagy associated 1; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity) (1661 aa)
ACADSacyl-CoA dehydrogenase, C-2 to C-3 short chain (412 aa)
ACAT1acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
ACAA2acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
ACSM3acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) (586 aa)
ACSM1acyl-CoA synthetase medium-chain family member 1; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity) (577 aa)
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
ACSM2Bacyl-CoA synthetase medium-chain family member 2B; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (577 aa)
ACSM5acyl-CoA synthetase medium-chain family member 5; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) (579 aa)
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and [...] (529 aa)
ACAA1acetyl-CoA acyltransferase 1 (424 aa)
SOGA2SOGA family member 2 (1586 aa)
ZNF830zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) (372 aa)
ACAT2acetyl-CoA acetyltransferase 2 (397 aa)
SOGA3SOGA family member 3 (947 aa)
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (290 aa)
DBTdihydrolipoamide branched chain transacylase E2; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components- branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (482 aa)
SEPHS1selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP (392 aa)
HIVEP1human immunodeficiency virus type I enhancer binding protein 1; This protein specifically binds to the DNA sequence 5’- GGGACTTTCC-3’ which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequ [...] (2718 aa)
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
ACSM4acyl-CoA synthetase medium-chain family member 4; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) (580 aa)
SEPHS2selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP (448 aa)
C6orf174C6orf174 protein (947 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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