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DARS DARS XPNPEP1 XPNPEP1 PET112 PET112 NARS2 NARS2 NARS NARS XPNPEP2 XPNPEP2 STK16 STK16 XPNPEP3 XPNPEP3 PEPD PEPD FAAH FAAH UQCRC1 UQCRC1 PMPCB PMPCB PMPCA PMPCA PDHB PDHB UQCRC2 UQCRC2 BCKDHB BCKDHB ACACA ACACA ACACB ACACB ALDH18A1 ALDH18A1 ENSG00000215472 ENSG00000215472 NOTCH2NL NOTCH2NL UBQLN4 UBQLN4 RPL17 RPL17 MRPL22 MRPL22 UBA52 UBA52 PSMD3 PSMD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UQCRC1ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (480 aa)
FAAHfatty acid amide hydrolase; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (579 aa)
PEPDpeptidase D (493 aa)
PMPCBpeptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (489 aa)
NARSasparaginyl-tRNA synthetase (548 aa)
PET112PET112 homolog (yeast); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) (557 aa)
DARSaspartyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (501 aa)
PSMD3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (534 aa)
UQCRC2ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (453 aa)
NARS2asparaginyl-tRNA synthetase 2, mitochondrial (putative) (477 aa)
PDHBpyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (359 aa)
BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components- branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (392 aa)
ACACBacetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
ACACAacetyl-CoA carboxylase alpha (2383 aa)
XPNPEP3X-prolyl aminopeptidase (aminopeptidase P) 3, putative (507 aa)
NOTCH2NLnotch 2 N-terminal like; May function in the Notch signaling pathway and regulate neutrophil differentiation (236 aa)
UBQLN4ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation (601 aa)
XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin (674 aa)
ALDH18A1aldehyde dehydrogenase 18 family, member A1 (795 aa)
PMPCApeptidase (mitochondrial processing) alpha; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (525 aa)
STK16serine/threonine kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins (305 aa)
UBA52ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa)
ENSG0000021547260S ribosomal protein L17 isoform a (184 aa)
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (666 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
RPL17ribosomal protein L17 (184 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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