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PNKD PNKD LACTB2 LACTB2 ACSF3 ACSF3 HAGH HAGH MCCC1 MCCC1 LDHD LDHD ALDH1A2 ALDH1A2 ECHDC1 ECHDC1 MCEE MCEE HAGHL HAGHL ACACB ACACB ENSG00000255275 ENSG00000255275 MCCC2 MCCC2 ACACA ACACA PCCA PCCA PCCB PCCB ENSG00000259131 ENSG00000259131 MUT MUT ALDH3B2 ALDH3B2 CARNS1 CARNS1 ENSG00000257767 ENSG00000257767 DHCR24 DHCR24 AGPS AGPS ALDH7A1 ALDH7A1 ALDH3A2 ALDH3A2 ALDH3A1 ALDH3A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ALDH3A1aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
MCEEmethylmalonyl CoA epimerase (176 aa)
ALDH1A2aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
ALDH3B2aldehyde dehydrogenase 3 family, member B2 (385 aa)
AGPSalkylglycerone phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids (By similarity) (658 aa)
MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha) (725 aa)
PNKDparoxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) (385 aa)
MUTmethylmalonyl CoA mutase; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (750 aa)
LACTB2lactamase, beta 2 (288 aa)
LDHDlactate dehydrogenase D (507 aa)
ACSF3acyl-CoA synthetase family member 3; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (576 aa)
ACACBacetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
MCCC2methylcrotonoyl-CoA carboxylase 2 (beta) (563 aa)
ACACAacetyl-CoA carboxylase alpha (2383 aa)
ALDH3A2aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
DHCR2424-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (516 aa)
PCCApropionyl CoA carboxylase, alpha polypeptide (728 aa)
HAGHLhydroxyacylglutathione hydrolase-like; Hydrolase acting on ester bonds (Potential) (282 aa)
HAGHhydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (308 aa)
ALDH7A1aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (539 aa)
CARNS1carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
PCCBpropionyl CoA carboxylase, beta polypeptide (559 aa)
ECHDC1enoyl CoA hydratase domain containing 1 (307 aa)
ENSG00000257767Uncharacterized protein (245 aa)
ENSG00000259131metallo-beta-lactamase domain containing 2 (279 aa)
ENSG00000255275annotation not available (296 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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