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STRINGSTRING
SURF6 SURF6 RRP36 RRP36 EBNA1BP2 EBNA1BP2 MRTO4 MRTO4 KCTD19 KCTD19 DDX10 DDX10 KRR1 KRR1 RPLP0 RPLP0 PNO1 PNO1 MFAP1 MFAP1 FBL FBL DDX18 DDX18 PTBP3 PTBP3 NOL6 NOL6 UBC UBC ENSG00000263020 ENSG00000263020 CSNK2A1 CSNK2A1 CSNK2A2 CSNK2A2 CSNK2B CSNK2B RAD51 RAD51 DMC1 DMC1 RAD51C RAD51C XRCC3 XRCC3 RAD51B RAD51B RAD51D RAD51D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast); May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity) (340 aa)
CSNK2A1casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] (391 aa)
FBLfibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa)
KRR1KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) (381 aa)
RRP36ribosomal RNA processing 36 homolog (S. cerevisiae); Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA (259 aa)
CSNK2A2casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] (350 aa)
DDX18DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; Probable RNA-dependent helicase (670 aa)
PNO1partner of NOB1 homolog (S. cerevisiae) (252 aa)
MFAP1microfibrillar-associated protein 1; Component of the elastin-associated microfibrils (439 aa)
NOL6nucleolar protein family 6 (RNA-associated) (1146 aa)
KCTD19potassium channel tetramerisation domain containing 19 (926 aa)
DDX10DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; Putative ATP-dependent RNA helicase (875 aa)
PTBP3polypyrimidine tract binding protein 3 (555 aa)
RAD51CRAD51 homolog C (S. cerevisiae); Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in t [...] (376 aa)
RPLP0ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity) (317 aa)
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (346 aa)
UBCubiquitin C (685 aa)
SURF6surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) (361 aa)
MRTO4mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa)
CSNK2Bcasein kinase 2, beta polypeptide (215 aa)
ENSG00000263020Lymphocyte antigen 6 complex, locus G5B (228 aa)
RAD51RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (340 aa)
EBNA1BP2EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa)
RAD51BRAD51 homolog B (S. cerevisiae) (384 aa)
RAD51DRAD51 homolog D (S. cerevisiae) (348 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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