Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ABCC6 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (1503 aa) | ||
 | EMC9 | ER membrane protein complex subunit 9 (208 aa) | ||
 | EMC2 | ER membrane protein complex subunit 2 (297 aa) | ||
 | EMC3 | ER membrane protein complex subunit 3 (261 aa) | ||
 | EMC6 | ER membrane protein complex subunit 6 (110 aa) | ||
 | EMC8 | ER membrane protein complex subunit 8 (210 aa) | ||
 | EMC7 | ER membrane protein complex subunit 7 (242 aa) | ||
 | ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (1549 aa) | ||
 | PECR | peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (303 aa) | ||
 | EMC4 | ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa) | ||
 | ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (1527 aa) | ||
 | UBB | ubiquitin B (229 aa) | ||
 | MMGT1 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa) | ||
 | ABCC12 | ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity) (1359 aa) | ||
 | WRB | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane (174 aa) | ||
 | ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (1437 aa) | ||
 | EMC10 | ER membrane protein complex subunit 10 (262 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | ABCC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...] (1382 aa) | ||
 | ASNA1 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] (348 aa) | ||
 | ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa) | ||
 | ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification (1325 aa) | ||
 | ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release (1581 aa) | ||
 | ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (1531 aa) | ||
 | EMC1 | ER membrane protein complex subunit 1 (993 aa) | ||
 | FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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