Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | MRPS35 | mitochondrial ribosomal protein S35 (323 aa) | ||
 | MRPL32 | mitochondrial ribosomal protein L32 (188 aa) | ||
 | MRPL27 | mitochondrial ribosomal protein L27 (148 aa) | ||
 | MRPS2 | mitochondrial ribosomal protein S2 (296 aa) | ||
 | MRPS7 | mitochondrial ribosomal protein S7 (242 aa) | ||
 | MRPL34 | mitochondrial ribosomal protein L34 (92 aa) | ||
 | EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction [...] (315 aa) | ||
 | MRPS5 | mitochondrial ribosomal protein S5 (430 aa) | ||
 | RPS23 | ribosomal protein S23 (143 aa) | ||
 | RPS9 | ribosomal protein S9 (194 aa) | ||
 | MRPL38 | mitochondrial ribosomal protein L38 (380 aa) | ||
 | RPS15A | ribosomal protein S15a (130 aa) | ||
 | GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis (222 aa) | ||
 | MRPL40 | mitochondrial ribosomal protein L40 (206 aa) | ||
 | MRPL20 | mitochondrial ribosomal protein L20 (149 aa) | ||
 | MTRF1L | mitochondrial translational release factor 1-like; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG (380 aa) | ||
 | MRPL23 | mitochondrial ribosomal protein L23 (153 aa) | ||
 | MRPL36 | mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa) | ||
 | MRPL19 | mitochondrial ribosomal protein L19 (292 aa) | ||
 | RPS29 | ribosomal protein S29 (67 aa) | ||
 | RPS8 | ribosomal protein S8 (208 aa) | ||
 | RPS18 | ribosomal protein S18 (152 aa) | ||
 | FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa) | ||
 | RPS25 | ribosomal protein S25 (125 aa) | ||
 | RPS15 | ribosomal protein S15 (145 aa) | ||
 | RPS28 | ribosomal protein S28 (69 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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