node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARTN | GDNF | ENSP00000387435 | ENSP00000409007 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | glial cell derived neurotrophic factor | 0.920 |
ARTN | GFRA1 | ENSP00000387435 | ENSP00000393725 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | 0.966 |
ARTN | GFRA4 | ENSP00000387435 | ENSP00000313423 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | GDNF family receptor alpha 4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla | 0.749 |
ARTN | NCAM1 | ENSP00000387435 | ENSP00000318472 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | neural cell adhesion molecule 1 | 0.900 |
ARTN | NRTN | ENSP00000387435 | ENSP00000302648 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.921 |
ARTN | PSPN | ENSP00000387435 | ENSP00000245810 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons | 0.915 |
GDNF | ARTN | ENSP00000409007 | ENSP00000387435 | glial cell derived neurotrophic factor | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | 0.920 |
GDNF | GFRA1 | ENSP00000409007 | ENSP00000393725 | glial cell derived neurotrophic factor | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | 0.999 |
GDNF | GFRA4 | ENSP00000409007 | ENSP00000313423 | glial cell derived neurotrophic factor | GDNF family receptor alpha 4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla | 0.512 |
GDNF | NCAM1 | ENSP00000409007 | ENSP00000318472 | glial cell derived neurotrophic factor | neural cell adhesion molecule 1 | 0.916 |
GDNF | NRTN | ENSP00000409007 | ENSP00000302648 | glial cell derived neurotrophic factor | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.919 |
GDNF | PSPN | ENSP00000409007 | ENSP00000245810 | glial cell derived neurotrophic factor | persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons | 0.916 |
GFRA1 | ARTN | ENSP00000393725 | ENSP00000387435 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | 0.966 |
GFRA1 | GDNF | ENSP00000393725 | ENSP00000409007 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | glial cell derived neurotrophic factor | 0.999 |
GFRA1 | NCAM1 | ENSP00000393725 | ENSP00000318472 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | neural cell adhesion molecule 1 | 0.917 |
GFRA1 | NRTN | ENSP00000393725 | ENSP00000302648 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.995 |
GFRA1 | PSPN | ENSP00000393725 | ENSP00000245810 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons | 0.969 |
GFRA4 | ARTN | ENSP00000313423 | ENSP00000387435 | GDNF family receptor alpha 4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | 0.749 |
GFRA4 | GDNF | ENSP00000313423 | ENSP00000409007 | GDNF family receptor alpha 4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla | glial cell derived neurotrophic factor | 0.512 |
GFRA4 | NRTN | ENSP00000313423 | ENSP00000302648 | GDNF family receptor alpha 4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.623 |