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STRINGSTRING
SNX7 SNX7 SNX30 SNX30 RTN2 RTN2 SNX12 SNX12 SNX10 SNX10 SNX4 SNX4 BCL2L1 BCL2L1 SNX11 SNX11 WDR20 WDR20 SNX8 SNX8 SNX2 SNX2 WDFY2 WDFY2 ENSG00000248710 ENSG00000248710 SNX1 SNX1 SNX3 SNX3 KIAA1715 KIAA1715 EML6 EML6 WDFY1 WDFY1 NWD1 NWD1 SEC61B SEC61B MOSPD3 MOSPD3 BRWD3 BRWD3 FANCG FANCG VAPB VAPB TBL1XR1 TBL1XR1 VAPA VAPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SNX8sorting nexin 8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (465 aa)
MOSPD3motile sperm domain containing 3 (235 aa)
SEC61BSec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum (96 aa)
SNX3sorting nexin 3 (162 aa)
WDFY1WD repeat and FYVE domain containing 1 (410 aa)
RTN2reticulon 2 (545 aa)
SNX4sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (450 aa)
KIAA1715KIAA1715; May be involved in limb and central nervous system development (By similarity) (428 aa)
WDFY2WD repeat and FYVE domain containing 2 (400 aa)
BCL2L1BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (233 aa)
SNX7sorting nexin 7 (451 aa)
SNX10sorting nexin 10; May be involved in several stages of intracellular trafficking (By similarity). May play a role in endosome homeostasis. Overexpression causes formation of huge vacuoles (201 aa)
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking (294 aa)
EML6echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) (1958 aa)
SNX11sorting nexin 11; May be involved in several stages of intracellular trafficking (By similarity) (270 aa)
BRWD3bromodomain and WD repeat domain containing 3 (1802 aa)
SNX30sorting nexin family member 30; May be involved in several stages of intracellular trafficking (By similarity) (437 aa)
SNX12sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity) (162 aa)
FANCGFanconi anemia, complementation group G; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (622 aa)
SNX2sorting nexin 2; May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (519 aa)
NWD1NACHT and WD repeat domain containing 1 (1432 aa)
TBL1XR1transducin (beta)-like 1 X-linked receptor 1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (514 aa)
WDR20WD repeat domain 20 (600 aa)
VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation (243 aa)
SNX1sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (522 aa)
ENSG00000248710Uncharacterized protein (948 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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