Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane (728 aa) | ||
 | KRT38 | keratin 38 (456 aa) | ||
 | KRT6C | keratin 6C (564 aa) | ||
 | KRT6B | keratin 6B (564 aa) | ||
 | USHBP1 | Usher syndrome 1C binding protein 1 (703 aa) | ||
 | HDAC4 | histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D (1084 aa) | ||
 | KRT71 | keratin 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (523 aa) | ||
 | KRT8 | keratin 8 (483 aa) | ||
 | KRT83 | keratin 83 (493 aa) | ||
 | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (247 aa) | ||
 | KRT2 | keratin 2; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (639 aa) | ||
 | HMG20B | high mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (317 aa) | ||
 | KRT79 | keratin 79 (535 aa) | ||
 | HGS | hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa) | ||
 | TXLNB | taxilin beta; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic (684 aa) | ||
 | ANKRD36BP1 | ankyrin repeat domain 36B pseudogene 1 (119 aa) | ||
 | CEP57L1 | centrosomal protein 57kDa-like 1; Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity) (460 aa) | ||
 | CD300A | CD300a molecule; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (299 aa) | ||
 | EPS15 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] (896 aa) | ||
 | TXLNA | taxilin alpha (546 aa) | ||
 | GNG10 | guanine nucleotide binding protein (G protein), gamma 10; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (68 aa) | ||
 | MAGEB4 | melanoma antigen family B, 4 (346 aa) | ||
 | KRT6A | keratin 6A (564 aa) | ||
 | KDM1A | lysine (K)-specific demethylase 1A (876 aa) | ||
 | KRT4 | keratin 4 (520 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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