| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAX | BCL2L1 | ENSP00000293288 | ENSP00000302564 | BCL2-associated X protein | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.999 |
| BAX | HSPA4 | ENSP00000293288 | ENSP00000302961 | BCL2-associated X protein | heat shock 70kDa protein 4 | 0.824 |
| BAX | TP53 | ENSP00000293288 | ENSP00000269305 | BCL2-associated X protein | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.999 |
| BAX | UBC | ENSP00000293288 | ENSP00000344818 | BCL2-associated X protein | ubiquitin C | 0.945 |
| BCL2L1 | BAX | ENSP00000302564 | ENSP00000293288 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | BCL2-associated X protein | 0.999 |
| BCL2L1 | BCL2L12 | ENSP00000302564 | ENSP00000246785 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | BCL2-like 12 (proline rich) | 0.932 |
| BCL2L1 | TP53 | ENSP00000302564 | ENSP00000269305 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.999 |
| BCL2L1 | UBC | ENSP00000302564 | ENSP00000344818 | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | ubiquitin C | 0.983 |
| BCL2L12 | BCL2L1 | ENSP00000246785 | ENSP00000302564 | BCL2-like 12 (proline rich) | BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis | 0.932 |
| BCL2L12 | HSPA4 | ENSP00000246785 | ENSP00000302961 | BCL2-like 12 (proline rich) | heat shock 70kDa protein 4 | 0.576 |
| BCL2L12 | TP53 | ENSP00000246785 | ENSP00000269305 | BCL2-like 12 (proline rich) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.859 |
| BCL2L12 | UBC | ENSP00000246785 | ENSP00000344818 | BCL2-like 12 (proline rich) | ubiquitin C | 0.837 |
| HSPA1A | HSPA4 | ENSP00000364802 | ENSP00000302961 | heat shock 70kDa protein 1A | heat shock 70kDa protein 4 | 0.560 |
| HSPA1A | TP53 | ENSP00000364802 | ENSP00000269305 | heat shock 70kDa protein 1A | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.796 |
| HSPA1A | UBC | ENSP00000364802 | ENSP00000344818 | heat shock 70kDa protein 1A | ubiquitin C | 0.416 |
| HSPA1B | HSPA4 | ENSP00000364801 | ENSP00000302961 | heat shock 70kDa protein 1B | heat shock 70kDa protein 4 | 0.549 |
| HSPA1B | TP53 | ENSP00000364801 | ENSP00000269305 | heat shock 70kDa protein 1B | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.490 |
| HSPA1B | UBC | ENSP00000364801 | ENSP00000344818 | heat shock 70kDa protein 1B | ubiquitin C | 0.416 |
| HSPA4 | BAX | ENSP00000302961 | ENSP00000293288 | heat shock 70kDa protein 4 | BCL2-associated X protein | 0.824 |
| HSPA4 | BCL2L12 | ENSP00000302961 | ENSP00000246785 | heat shock 70kDa protein 4 | BCL2-like 12 (proline rich) | 0.576 |
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