node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMWD | SDF2 | ENSP00000270223 | ENSP00000247020 | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis | stromal cell-derived factor 2 | 0.740 |
DNAJA2 | DNAJB1 | ENSP00000314030 | ENSP00000254322 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | 0.796 |
DNAJA2 | DNAJB4 | ENSP00000314030 | ENSP00000359799 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | DnaJ (Hsp40) homolog, subfamily B, member 4; Probable chaperone | 0.759 |
DNAJA2 | DNAJB5 | ENSP00000314030 | ENSP00000404079 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.780 |
DNAJA2 | HSPA5 | ENSP00000314030 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.938 |
DNAJB1 | DNAJA2 | ENSP00000254322 | ENSP00000314030 | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | 0.796 |
DNAJB1 | DNAJC3 | ENSP00000254322 | ENSP00000365991 | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.940 |
DNAJB1 | HSPA5 | ENSP00000254322 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.955 |
DNAJB11 | DNAJC3 | ENSP00000265028 | ENSP00000365991 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.977 |
DNAJB11 | HSPA5 | ENSP00000265028 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.974 |
DNAJB11 | SDF2 | ENSP00000265028 | ENSP00000247020 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | stromal cell-derived factor 2 | 0.609 |
DNAJB4 | DNAJA2 | ENSP00000359799 | ENSP00000314030 | DnaJ (Hsp40) homolog, subfamily B, member 4; Probable chaperone | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | 0.759 |
DNAJB4 | HSPA5 | ENSP00000359799 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily B, member 4; Probable chaperone | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.914 |
DNAJB5 | DNAJA2 | ENSP00000404079 | ENSP00000314030 | DnaJ (Hsp40) homolog, subfamily B, member 5 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | 0.780 |
DNAJB5 | HSPA5 | ENSP00000404079 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily B, member 5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.905 |
DNAJC3 | DNAJB1 | ENSP00000365991 | ENSP00000254322 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | 0.940 |
DNAJC3 | DNAJB11 | ENSP00000365991 | ENSP00000265028 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.977 |
DNAJC3 | HSPA5 | ENSP00000365991 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.917 |
HNRNPD | HSPA5 | ENSP00000313199 | ENSP00000324173 | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.493 |
HSPA5 | DNAJA2 | ENSP00000324173 | ENSP00000314030 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | 0.938 |