node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF3F | NOTCH1 | ENSP00000310040 | ENSP00000277541 | eukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.637 |
FGA | FGB | ENSP00000306361 | ENSP00000306099 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.999 |
FGA | FGG | ENSP00000306361 | ENSP00000336829 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen gamma chain | 0.999 |
FGA | FGL1 | ENSP00000306361 | ENSP00000221204 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen-like 1; Has hepatocyte mitogenic activity | 0.734 |
FGA | FGL2 | ENSP00000306361 | ENSP00000248598 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen-like 2; May play a role in physiologic lymphocyte functions at mucosal sites | 0.766 |
FGA | FN1 | ENSP00000306361 | ENSP00000346839 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibronectin 1 | 0.823 |
FGA | SERPINF2 | ENSP00000306361 | ENSP00000321853 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.909 |
FGA | THBS1 | ENSP00000306361 | ENSP00000260356 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.902 |
FGB | FGA | ENSP00000306099 | ENSP00000306361 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.999 |
FGB | FGG | ENSP00000306099 | ENSP00000336829 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen gamma chain | 0.999 |
FGB | FGL1 | ENSP00000306099 | ENSP00000221204 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen-like 1; Has hepatocyte mitogenic activity | 0.750 |
FGB | FGL2 | ENSP00000306099 | ENSP00000248598 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibrinogen-like 2; May play a role in physiologic lymphocyte functions at mucosal sites | 0.773 |
FGB | FN1 | ENSP00000306099 | ENSP00000346839 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | fibronectin 1 | 0.797 |
FGB | SERPINF2 | ENSP00000306099 | ENSP00000321853 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.782 |
FGB | THBS1 | ENSP00000306099 | ENSP00000260356 | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.736 |
FGG | FGA | ENSP00000336829 | ENSP00000306361 | fibrinogen gamma chain | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.999 |
FGG | FGB | ENSP00000336829 | ENSP00000306099 | fibrinogen gamma chain | fibrinogen beta chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.999 |
FGG | FGL1 | ENSP00000336829 | ENSP00000221204 | fibrinogen gamma chain | fibrinogen-like 1; Has hepatocyte mitogenic activity | 0.744 |
FGG | FGL2 | ENSP00000336829 | ENSP00000248598 | fibrinogen gamma chain | fibrinogen-like 2; May play a role in physiologic lymphocyte functions at mucosal sites | 0.771 |
FGG | FN1 | ENSP00000336829 | ENSP00000346839 | fibrinogen gamma chain | fibronectin 1 | 0.808 |