Your Input:
|
||||
MGST1 | microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity (155 aa) | |||
GSTA3 | glutathione S-transferase alpha 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (222 aa) | |||
GSS | glutathione synthetase (474 aa) | |||
GCLC | glutamate-cysteine ligase, catalytic subunit (637 aa) | |||
GSTM2 | glutathione S-transferase mu 2 (muscle); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa) | |||
GGT1 | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive (569 aa) | |||
GSTT1 | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide (240 aa) | |||
GSTM5 | glutathione S-transferase mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa) | |||
GSTM3 | glutathione S-transferase mu 3 (brain); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers (225 aa) | |||
BAAT | bile acid CoA- amino acid N-acyltransferase (glycine N-choloyltransferase); Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation [...] (418 aa) | |||
MGST2 | microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione (147 aa) | |||
CSAD | cysteine sulfinic acid decarboxylase (520 aa) | |||
GGCT | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (188 aa) | |||
GSTA5 | glutathione S-transferase alpha 5 (222 aa) | |||
GSTA1 | glutathione S-transferase alpha 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (222 aa) | |||
GSTO2 | glutathione S-transferase omega 2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (243 aa) | |||
GAD1 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA (594 aa) | |||
GPX7 | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (187 aa) | |||
MGST3 | microsomal glutathione S-transferase 3; Also functions as a glutathione peroxidase (152 aa) | |||
GCLM | glutamate-cysteine ligase, modifier subunit (274 aa) | |||
TXNDC12 | thioredoxin domain containing 12 (endoplasmic reticulum); Possesses significant protein thiol-disulfide oxidase activity (172 aa) | |||
GPX3 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (226 aa) | |||
GPX2 | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors (190 aa) | |||
GSTP1 | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (210 aa) | |||
GSTA2 | glutathione S-transferase alpha 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (222 aa) | |||
GSTK1 | glutathione S-transferase kappa 1; Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (282 aa) |