node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX15B | CTF1 | ENSP00000369530 | ENSP00000279804 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | 0.900 |
ALOX15B | GRB2 | ENSP00000369530 | ENSP00000339007 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.900 |
ALOX15B | HBEGF | ENSP00000369530 | ENSP00000230990 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | heparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor | 0.900 |
ALOX15B | IGF1 | ENSP00000369530 | ENSP00000302665 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | 0.904 |
ALOX15B | LIF | ENSP00000369530 | ENSP00000249075 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes | 0.900 |
ALOX15B | SHC1 | ENSP00000369530 | ENSP00000401303 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | SHC (Src homology 2 domain containing) transforming protein 1 | 0.900 |
ALOX15B | SOS1 | ENSP00000369530 | ENSP00000384675 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.900 |
CSF3R | CTF1 | ENSP00000362195 | ENSP00000279804 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | 0.832 |
CSF3R | GRB2 | ENSP00000362195 | ENSP00000339007 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.827 |
CSF3R | JAK1 | ENSP00000362195 | ENSP00000343204 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.940 |
CSF3R | JAK2 | ENSP00000362195 | ENSP00000371067 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.952 |
CSF3R | LIF | ENSP00000362195 | ENSP00000249075 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes | 0.576 |
CSF3R | SHC1 | ENSP00000362195 | ENSP00000401303 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | SHC (Src homology 2 domain containing) transforming protein 1 | 0.834 |
CSF3R | TYK2 | ENSP00000362195 | ENSP00000264818 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.854 |
CTF1 | ALOX15B | ENSP00000279804 | ENSP00000369530 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.900 |
CTF1 | CSF3R | ENSP00000279804 | ENSP00000362195 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | 0.832 |
CTF1 | GRB2 | ENSP00000279804 | ENSP00000339007 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.921 |
CTF1 | HBEGF | ENSP00000279804 | ENSP00000230990 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | heparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor | 0.982 |
CTF1 | IGF1 | ENSP00000279804 | ENSP00000302665 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | 0.943 |
CTF1 | IL6ST | ENSP00000279804 | ENSP00000338799 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events | 0.946 |