node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDC | GCH1 | ENSP00000350616 | ENSP00000378890 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | 0.582 |
DDC | IDO1 | ENSP00000350616 | ENSP00000430505 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | 0.903 |
DDC | IDO2 | ENSP00000350616 | ENSP00000443432 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism | 0.900 |
DDC | IL4I1 | ENSP00000350616 | ENSP00000342557 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.900 |
DDC | TPH1 | ENSP00000350616 | ENSP00000250018 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | tryptophan hydroxylase 1 | 0.969 |
DDC | TPH2 | ENSP00000350616 | ENSP00000329093 | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | tryptophan hydroxylase 2 | 0.948 |
GAD1 | GAD2 | ENSP00000350928 | ENSP00000259271 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.919 |
GAD1 | IL4I1 | ENSP00000350928 | ENSP00000342557 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.800 |
GAD1 | PRKACA | ENSP00000350928 | ENSP00000309591 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.598 |
GAD2 | GAD1 | ENSP00000259271 | ENSP00000350928 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.919 |
GAD2 | IL4I1 | ENSP00000259271 | ENSP00000342557 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.800 |
GAD2 | PRKACA | ENSP00000259271 | ENSP00000309591 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.598 |
GAD2 | TPH1 | ENSP00000259271 | ENSP00000250018 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | tryptophan hydroxylase 1 | 0.402 |
GATA3 | MYC | ENSP00000368632 | ENSP00000367207 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.866 |
GCH1 | DDC | ENSP00000378890 | ENSP00000350616 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | 0.582 |
GCH1 | TPH1 | ENSP00000378890 | ENSP00000250018 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown | tryptophan hydroxylase 1 | 0.598 |
HDC | TPH1 | ENSP00000267845 | ENSP00000250018 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | tryptophan hydroxylase 1 | 0.519 |
IDO1 | DDC | ENSP00000430505 | ENSP00000350616 | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine | 0.903 |
IDO1 | IL4I1 | ENSP00000430505 | ENSP00000342557 | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) | 0.901 |
IDO1 | TPH1 | ENSP00000430505 | ENSP00000250018 | indoleamine 2,3-dioxygenase 1; Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen | tryptophan hydroxylase 1 | 0.917 |