26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPB6	heat shock protein, alpha-crystallin-related, B6 (160 aa)
	UQCRC1	ubiquinol-cytochrome c reductase core protein I; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (480 aa)
	CRYAB	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (175 aa)
	HSPB1	heat shock 27kDa protein 1 (205 aa)
	PMPCB	peptidase (mitochondrial processing) beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (489 aa)
	QTRT1	queuine tRNA-ribosyltransferase 1; Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) (403 aa)
	UQCRC2	ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (453 aa)
	QTRTD1	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) (415 aa)
	HSPB8	heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity (196 aa)
	CRYAA	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (173 aa)
	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on ’Tyr-142’ (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro- apoptosis factors such a [...] (708 aa)
	ENSG00000170276	Heat shock protein beta-2 (182 aa)
	HSPB3	heat shock 27kDa protein 3; Inhibitor of actin polymerization (150 aa)
	HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular) (170 aa)
	DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2; Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation (885 aa)
	DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (1054 aa)
	HSPD1	heat shock 60kDa protein 1 (chaperonin); Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (573 aa)
	HSPB9	heat shock protein, alpha-crystallin-related, B9 (159 aa)
	PMPCA	peptidase (mitochondrial processing) alpha; Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity) (525 aa)
	DIS3	DIS3 mitotic control homolog (S. cerevisiae) (958 aa)
	THUMPD1	THUMP domain containing 1 (353 aa)
	PRAME	preferentially expressed antigen in melanoma; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (509 aa)
	HELZ2	helicase with zinc finger 2, transcriptional coactivator; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (2649 aa)
	POLE4	polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function (117 aa)
	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalization of beta-amyloid precursor protein (759 aa)
	HSPB2	HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK (182 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYAA	CRYAB	ENSP00000291554	ENSP00000227251	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.701
CRYAA	HSPB1	ENSP00000291554	ENSP00000248553	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	heat shock 27kDa protein 1	0.821
CRYAA	HSPB2	ENSP00000291554	ENSP00000457706	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK	0.606
CRYAA	HSPB7	ENSP00000291554	ENSP00000310111	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	heat shock 27kDa protein family, member 7 (cardiovascular)	0.472
CRYAA	HSPB9	ENSP00000291554	ENSP00000347178	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	heat shock protein, alpha-crystallin-related, B9	0.531
CRYAB	CRYAA	ENSP00000227251	ENSP00000291554	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.701
CRYAB	HSPB1	ENSP00000227251	ENSP00000248553	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	heat shock 27kDa protein 1	0.672
CRYAB	HSPB9	ENSP00000227251	ENSP00000347178	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	heat shock protein, alpha-crystallin-related, B9	0.516
DIS3	DIS3L	ENSP00000366997	ENSP00000321711	DIS3 mitotic control homolog (S. cerevisiae)	DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA	0.915
DIS3L	DIS3	ENSP00000321711	ENSP00000366997	DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA	DIS3 mitotic control homolog (S. cerevisiae)	0.915
ENSG00000170276	HSPB1	ENSP00000302476	ENSP00000248553	Heat shock protein beta-2	heat shock 27kDa protein 1	0.910
ENSG00000170276	HSPB3	ENSP00000302476	ENSP00000303394	Heat shock protein beta-2	heat shock 27kDa protein 3; Inhibitor of actin polymerization	0.630
HSPB1	CRYAA	ENSP00000248553	ENSP00000291554	heat shock 27kDa protein 1	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.821
HSPB1	CRYAB	ENSP00000248553	ENSP00000227251	heat shock 27kDa protein 1	crystallin, alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.672
HSPB1	ENSG00000170276	ENSP00000248553	ENSP00000302476	heat shock 27kDa protein 1	Heat shock protein beta-2	0.910
HSPB1	HSPB8	ENSP00000248553	ENSP00000281938	heat shock 27kDa protein 1	heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity	0.925
HSPB1	HSPB9	ENSP00000248553	ENSP00000347178	heat shock 27kDa protein 1	heat shock protein, alpha-crystallin-related, B9	0.418
HSPB1	HSPD1	ENSP00000248553	ENSP00000340019	heat shock 27kDa protein 1	heat shock 60kDa protein 1 (chaperonin); Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix	0.578
HSPB2	CRYAA	ENSP00000457706	ENSP00000291554	HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.606
HSPB2	HSPB3	ENSP00000457706	ENSP00000303394	HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK	heat shock 27kDa protein 3; Inhibitor of actin polymerization	0.648

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