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STRINGSTRING
PCSK4 PCSK4 PCSK2 PCSK2 PI4KB PI4KB PPTC7 PPTC7 PCYT1A PCYT1A MOSPD2 MOSPD2 CHKA CHKA SACM1L SACM1L CHKB CHKB PLD2 PLD2 SEC14L5 SEC14L5 PCSK6 PCSK6 ARFGAP1 ARFGAP1 PCYT1B PCYT1B PLD1 PLD1 FURIN FURIN ARL1 ARL1 STX16 STX16 PFDN5 PFDN5 ARFRP1 ARFRP1 TBC1D22B TBC1D22B ENSG00000254995 ENSG00000254995 RAB1B RAB1B TBC1D22A TBC1D22A RAB1A RAB1A TRAPPC8 TRAPPC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SEC14L5SEC14-like 5 (S. cerevisiae) (696 aa)
ARL1ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa)
PCSK2proprotein convertase subtilisin/kexin type 2 (638 aa)
PLD2phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
CHKAcholine kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (457 aa)
FURINfurin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif (794 aa)
PI4KBphosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (828 aa)
TRAPPC8trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
PCYT1Aphosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis (367 aa)
PCSK4proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex (755 aa)
PCSK6proprotein convertase subtilisin/kexin type 6 (968 aa)
RAB1BRAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa)
ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (414 aa)
ARFRP1ADP-ribosylation factor related protein 1; Possibly involved in plasma membrane-related signaling events (201 aa)
PFDN5prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (154 aa)
TBC1D22ATBC1 domain family, member 22A (517 aa)
PLD1phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) (1074 aa)
PPTC7PTC7 protein phosphatase homolog (S. cerevisiae) (304 aa)
STX16syntaxin 16 (325 aa)
TBC1D22BTBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
PCYT1Bphosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis (369 aa)
MOSPD2motile sperm domain containing 2 (518 aa)
SACM1LSAC1 suppressor of actin mutations 1-like (yeast); Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity) (587 aa)
CHKBcholine kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (395 aa)
RAB1ARAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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