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HOXA5 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ (270 aa) | |||
IRX4 | iroquois homeobox 4; Likely to be an important mediator of ventricular differentiation during cardiac development (519 aa) | |||
HOXB5 | homeobox B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (269 aa) | |||
HOXD9 | homeobox D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (352 aa) | |||
PBX4 | pre-B-cell leukemia homeobox 4 (374 aa) | |||
MEIS1 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (390 aa) | |||
IRX6 | iroquois homeobox 6 (446 aa) | |||
PKNOX1 | PBX/knotted 1 homeobox 1 (436 aa) | |||
EN2 | engrailed homeobox 2 (333 aa) | |||
PKNOX2 | PBX/knotted 1 homeobox 2 (472 aa) | |||
IRX1 | iroquois homeobox 1 (480 aa) | |||
HOXC4 | homeobox C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (264 aa) | |||
IRX2 | iroquois homeobox 2 (471 aa) | |||
TGIF2LY | TGFB-induced factor homeobox 2-like, Y-linked; May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX (185 aa) | |||
TGIF1 | TGFB-induced factor homeobox 1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha [...] (401 aa) | |||
IRX3 | iroquois homeobox 3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity) (501 aa) | |||
HOXA1 | homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (335 aa) | |||
HOXA4 | homeobox A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5’-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5’-TAATGA[CG]-3’ and 5’-CTAATTTT- 3’ (320 aa) | |||
TGIF2LX | TGFB-induced factor homeobox 2-like, X-linked; May have a transcription role in testis (241 aa) | |||
IPO13 | importin 13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis r [...] (963 aa) | |||
TGIF2 | TGFB-induced factor homeobox 2; Transcriptional repressor, which probably repress transcription by binding directly the 5’-CTGTCAA-3’ DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (237 aa) | |||
MKX | mohawk homeobox; May act as a morphogenetic regulator of cell adhesion (By similarity) (352 aa) | |||
IRX5 | iroquois homeobox 5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12 (483 aa) | |||
MEIS3 | Meis homeobox 3 (421 aa) | |||
MEIS2 | Meis homeobox 2 (477 aa) | |||
ENSG00000259399 | TGIF2-C20orf24 protein (155 aa) |