Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | HOXA5 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ (270 aa) | ||
 | HOXA6 | homeobox A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (233 aa) | ||
 | HOXB6 | homeobox B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (224 aa) | ||
 | HOXB8 | homeobox B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (243 aa) | ||
 | HOXB5 | homeobox B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (269 aa) | ||
 | HOXB7 | homeobox B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (217 aa) | ||
 | HOXA7 | homeobox A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (230 aa) | ||
 | HOXC6 | homeobox C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (235 aa) | ||
 | PBX4 | pre-B-cell leukemia homeobox 4 (374 aa) | ||
 | MNX1 | motor neuron and pancreas homeobox 1; Putative transcription factor involved in pancreas development and function (401 aa) | ||
 | MEOX2 | mesenchyme homeobox 2; Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity) (304 aa) | ||
 | MEIS1 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (390 aa) | ||
 | HOXD4 | homeobox D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (255 aa) | ||
 | GSX1 | GS homeobox 1; Probable transcription factor that binds to the DNA sequence 5’-GC[TA][AC]ATTA[GA]-3’. Activates the transcription of the GHRH gene. Plays an important role in pituitary development (264 aa) | ||
 | HOXB3 | homeobox B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (431 aa) | ||
 | HOXC5 | homeobox C5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (222 aa) | ||
 | HOXD8 | homeobox D8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (290 aa) | ||
 | GSX2 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) (304 aa) | ||
 | MEOX1 | mesenchyme homeobox 1; Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation (By similarity) (254 aa) | ||
 | HOXB4 | homeobox B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (251 aa) | ||
 | HOXB2 | homeobox B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (356 aa) | ||
 | HOXA1 | homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (335 aa) | ||
 | HOXA4 | homeobox A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5’-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5’-TAATGA[CG]-3’ and 5’-CTAATTTT- 3’ (320 aa) | ||
 | HOXB1 | homeobox B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (301 aa) | ||
 | MEIS3 | Meis homeobox 3 (421 aa) | ||
 | MEIS2 | Meis homeobox 2 (477 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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