11 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 (489 aa)
	LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (439 aa)
	HLA-F	major histocompatibility complex, class I, F (442 aa)
	PTPN11	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (593 aa)
	HLA-G	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
	HLA-C	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
	HLA-E	major histocompatibility complex, class I, E (358 aa)
	HLA-A	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
	PTPN6	protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis (624 aa)
	HLA-B	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
	B2M	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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TSV: tab separated values - can be opened in Excel

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	HLA-A	ENSP00000452780	ENSP00000366005	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.998
B2M	HLA-B	ENSP00000452780	ENSP00000399168	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.999
B2M	HLA-C	ENSP00000452780	ENSP00000365402	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.986
B2M	HLA-E	ENSP00000452780	ENSP00000365817	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, E	0.790
B2M	HLA-F	ENSP00000452780	ENSP00000259951	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, F	0.691
B2M	HLA-G	ENSP00000452780	ENSP00000353472	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.924
HLA-A	B2M	ENSP00000366005	ENSP00000452780	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.998
HLA-A	HLA-B	ENSP00000366005	ENSP00000399168	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-A	HLA-C	ENSP00000366005	ENSP00000365402	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-A	HLA-G	ENSP00000366005	ENSP00000353472	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.544
HLA-B	B2M	ENSP00000399168	ENSP00000452780	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.999
HLA-B	HLA-A	ENSP00000399168	ENSP00000366005	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-B	HLA-C	ENSP00000399168	ENSP00000365402	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-B	HLA-G	ENSP00000399168	ENSP00000353472	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.546
HLA-C	B2M	ENSP00000365402	ENSP00000452780	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.986
HLA-C	HLA-A	ENSP00000365402	ENSP00000366005	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-C	HLA-B	ENSP00000365402	ENSP00000399168	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-C	HLA-G	ENSP00000365402	ENSP00000353472	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.545
HLA-E	B2M	ENSP00000365817	ENSP00000452780	major histocompatibility complex, class I, E	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.790
HLA-F	B2M	ENSP00000259951	ENSP00000452780	major histocompatibility complex, class I, F	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.691

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