node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS2 | BMP1 | ENSP00000251582 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | bone morphogenetic protein 1 | 0.941 |
ADAMTS2 | PCOLCE | ENSP00000251582 | ENSP00000223061 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.919 |
ADAMTS2 | PCOLCE2 | ENSP00000251582 | ENSP00000295992 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1 | 0.910 |
ADAMTS2 | TLL1 | ENSP00000251582 | ENSP00000061240 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.921 |
BMP1 | ADAMTS2 | ENSP00000305714 | ENSP00000251582 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.941 |
BMP1 | PCOLCE | ENSP00000305714 | ENSP00000223061 | bone morphogenetic protein 1 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.922 |
BMP1 | PCOLCE2 | ENSP00000305714 | ENSP00000295992 | bone morphogenetic protein 1 | procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1 | 0.921 |
BMP1 | TLL1 | ENSP00000305714 | ENSP00000061240 | bone morphogenetic protein 1 | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.901 |
PCOLCE | ADAMTS2 | ENSP00000223061 | ENSP00000251582 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.919 |
PCOLCE | BMP1 | ENSP00000223061 | ENSP00000305714 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | bone morphogenetic protein 1 | 0.922 |
PCOLCE2 | ADAMTS2 | ENSP00000295992 | ENSP00000251582 | procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.910 |
PCOLCE2 | BMP1 | ENSP00000295992 | ENSP00000305714 | procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1 | bone morphogenetic protein 1 | 0.921 |
PIK3R1 | PIK3R5 | ENSP00000274335 | ENSP00000392812 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | phosphoinositide-3-kinase, regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity) | 0.948 |
PIK3R5 | PIK3R1 | ENSP00000392812 | ENSP00000274335 | phosphoinositide-3-kinase, regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity) | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.948 |
TLL1 | ADAMTS2 | ENSP00000061240 | ENSP00000251582 | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.921 |
TLL1 | BMP1 | ENSP00000061240 | ENSP00000305714 | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | bone morphogenetic protein 1 | 0.901 |