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WWP2 WWP2 PTEN PTEN RER1 RER1 WWP1 WWP1 NEDD4 NEDD4 YAP1 YAP1 EGFR EGFR SLC11A1 SLC11A1 SLC11A2 SLC11A2 TSG101 TSG101 HECW1 HECW1 NEDD4L NEDD4L ITCH ITCH SOD3 SOD3 UBC UBC SOD1 SOD1 NDFIP1 NDFIP1 SMURF1 SMURF1 CCS CCS MAVS MAVS BAG3 BAG3 SMURF2 SMURF2 GAS7 GAS7 HECW2 HECW2 BRI3 BRI3 UEVLD UEVLD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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co-expression
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SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the catio [...] (550 aa)
TSG101tumor susceptibility gene 101; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P [...] (390 aa)
NDFIP1Nedd4 family interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through mult [...] (221 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (1572 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2 (748 aa)
WWP1WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] (922 aa)
SOD1superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (154 aa)
EGFRepidermal growth factor receptor (1210 aa)
YAP1Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...] (504 aa)
BRI3brain protein I3 (125 aa)
RER1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae); Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment (By similarity) (196 aa)
UBCubiquitin C (685 aa)
NEDD4neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (1247 aa)
WWP2WW domain containing E3 ubiquitin protein ligase 2 (870 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (757 aa)
BAG3BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity (575 aa)
PTENphosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
ITCHitchy E3 ubiquitin protein ligase (862 aa)
SOD3superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen (240 aa)
SLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (590 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS (1606 aa)
UEVLDUEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination (471 aa)
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (975 aa)
MAVSmitochondrial antiviral signaling protein (540 aa)
GAS7growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa)
CCScopper chaperone for superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (274 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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