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MPHOSPH10 | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa) | |||
UTP3 | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) (479 aa) | |||
KDM6B | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (1682 aa) | |||
UTP6 | UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (597 aa) | |||
NOP58 | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa) | |||
DVL3 | dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes (716 aa) | |||
PRPF31 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) (499 aa) | |||
CIRH1A | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa) | |||
NOC4L | nucleolar complex associated 4 homolog (S. cerevisiae) (516 aa) | |||
UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) (1347 aa) | |||
UGP2 | UDP-glucose pyrophosphorylase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways (508 aa) | |||
UBC | ubiquitin C (685 aa) | |||
COG2 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa) | |||
KDM5B | lysine (K)-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma (1544 aa) | |||
TPR | translocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa) | |||
UAP1 | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P (505 aa) | |||
KDM5C | lysine (K)-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (1560 aa) | |||
KDM6A | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (1401 aa) | |||
NOP56 | NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa) | |||
SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa) | |||
KDM5A | lysine (K)-specific demethylase 5A; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12 (1690 aa) | |||
CDCA7L | cell division cycle associated 7-like (454 aa) | |||
UAP1L1 | UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (507 aa) | |||
DIEXF | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) (756 aa) | |||
WDR36 | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa) | |||
KDM5D | lysine (K)-specific demethylase 5D; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May play a role in spermatogenesis (1570 aa) |