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UGP2 UGP2 CDCA7L CDCA7L UAP1L1 UAP1L1 UAP1 UAP1 DVL3 DVL3 PRPF31 PRPF31 UTP3 UTP3 NOC4L NOC4L COG2 COG2 UTP6 UTP6 CIRH1A CIRH1A UBC UBC NOP58 NOP58 NOP56 NOP56 MPHOSPH10 MPHOSPH10 SUMO1 SUMO1 KDM5B KDM5B WDR36 WDR36 KDM6B KDM6B DIEXF DIEXF KDM5A KDM5A TPR TPR KDM5C KDM5C KDM6A KDM6A KDM5D KDM5D UTY UTY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) (479 aa)
KDM6Blysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (1682 aa)
UTP6UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (597 aa)
NOP58NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa)
DVL3dishevelled, dsh homolog 3 (Drosophila); May play a role in the signal transduction pathway mediated by multiple Wnt genes (716 aa)
PRPF31PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) (499 aa)
CIRH1Acirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
UTYubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) (1347 aa)
UGP2UDP-glucose pyrophosphorylase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways (508 aa)
UBCubiquitin C (685 aa)
COG2component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
KDM5Blysine (K)-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma (1544 aa)
TPRtranslocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa)
UAP1UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P (505 aa)
KDM5Clysine (K)-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (1560 aa)
KDM6Alysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (1401 aa)
NOP56NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa)
KDM5Alysine (K)-specific demethylase 5A; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12 (1690 aa)
CDCA7Lcell division cycle associated 7-like (454 aa)
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (507 aa)
DIEXFdigestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) (756 aa)
WDR36WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa)
KDM5Dlysine (K)-specific demethylase 5D; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May play a role in spermatogenesis (1570 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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