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STRINGSTRING
IGFBP7 IGFBP7 LRRTM1 LRRTM1 PODN PODN PDGFRL PDGFRL HAPLN2 HAPLN2 LRRC8A LRRC8A KERA KERA FMOD FMOD CDON CDON LRRTM2 LRRTM2 BOC BOC LRRC8B LRRC8B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PDGFRLplatelet-derived growth factor receptor-like (375 aa)
HAPLN2hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) (340 aa)
LRRC8Aleucine rich repeat containing 8 family, member A; Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity) (810 aa)
CDONCdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity) (1264 aa)
KERAkeratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (352 aa)
LRRTM2leucine rich repeat transmembrane neuronal 2; Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity) (516 aa)
LRRTM1leucine rich repeat transmembrane neuronal 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level (By similarity) (522 aa)
IGFBP7insulin-like growth factor binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (282 aa)
PODNpodocan; Negatively regulates cell proliferation and cell migration (661 aa)
LRRC8Bleucine rich repeat containing 8 family, member B (803 aa)
FMODfibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) (376 aa)
BOCBoc homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (1114 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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