node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MTM1 | MTMR12 | ENSP00000359423 | ENSP00000371577 | myotubularin 1; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not [...] | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | 0.699 |
MTMR12 | MTM1 | ENSP00000371577 | ENSP00000359423 | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | myotubularin 1; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not [...] | 0.699 |
MTMR12 | MTMR2 | ENSP00000371577 | ENSP00000345752 | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | 0.686 |
MTMR12 | UBC | ENSP00000371577 | ENSP00000344818 | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | ubiquitin C | 0.739 |
MTMR2 | MTMR12 | ENSP00000345752 | ENSP00000371577 | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | 0.686 |
MTMR2 | UBC | ENSP00000345752 | ENSP00000344818 | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | ubiquitin C | 0.541 |
MTMR6 | MTMR8 | ENSP00000371221 | ENSP00000363985 | myotubularin related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells | myotubularin related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | 0.641 |
MTMR6 | MTMR9 | ENSP00000371221 | ENSP00000221086 | myotubularin related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.960 |
MTMR6 | UBC | ENSP00000371221 | ENSP00000344818 | myotubularin related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells | ubiquitin C | 0.818 |
MTMR7 | MTMR9 | ENSP00000180173 | ENSP00000221086 | myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.833 |
MTMR8 | MTMR6 | ENSP00000363985 | ENSP00000371221 | myotubularin related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | myotubularin related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells | 0.641 |
MTMR8 | MTMR9 | ENSP00000363985 | ENSP00000221086 | myotubularin related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.976 |
MTMR9 | MTMR6 | ENSP00000221086 | ENSP00000371221 | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | myotubularin related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells | 0.960 |
MTMR9 | MTMR7 | ENSP00000221086 | ENSP00000180173 | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | 0.833 |
MTMR9 | MTMR8 | ENSP00000221086 | ENSP00000363985 | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | myotubularin related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | 0.976 |
MTMR9 | UBC | ENSP00000221086 | ENSP00000344818 | myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | ubiquitin C | 0.516 |
PMS1 | UBC | ENSP00000406490 | ENSP00000344818 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | ubiquitin C | 0.591 |
SBF2 | UBC | ENSP00000256190 | ENSP00000344818 | SET binding factor 2 | ubiquitin C | 0.487 |
UBC | MTMR12 | ENSP00000344818 | ENSP00000371577 | ubiquitin C | myotubularin related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location | 0.739 |
UBC | MTMR2 | ENSP00000344818 | ENSP00000345752 | ubiquitin C | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | 0.541 |