26 items (Homo sapiens) - STRING network view

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	CD4	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa)
	ZP2	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (745 aa)
	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa)
	KLRK1	killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes (216 aa)
	ADAM20	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization (776 aa)
	MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa)
	ADAM2	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa)
	ADAM21	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients (722 aa)
	MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa)
	ZP1	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (638 aa)
	DCLK2	doublecortin-like kinase 2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity) (783 aa)
	AACS	acetoacetyl-CoA synthetase (672 aa)
	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (576 aa)
	ZP4	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor (540 aa)
	ADAM30	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization (790 aa)
	MPP1	membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa)
	OVGP1	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development (678 aa)
	CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
	B4GALT1	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (398 aa)
	ARSH	arylsulfatase family, member H (562 aa)
	ZP3	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation (424 aa)
	MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa)
	MPP4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); May play a role in retinal photoreceptors development (By similarity) (637 aa)
	ACAN	aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
	ENSG00000223931	annotation not available (97 aa)
	ENSG00000228325	Uncharacterized protein (130 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM2	ADAM20	ENSP00000265708	ENSP00000256389	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	0.917
ADAM2	ADAM21	ENSP00000265708	ENSP00000267499	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	0.914
ADAM2	ADAM30	ENSP00000265708	ENSP00000358407	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization	0.908
ADAM2	B4GALT1	ENSP00000265708	ENSP00000369055	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.900
ADAM2	OVGP1	ENSP00000265708	ENSP00000358747	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development	0.904
ADAM2	ZP1	ENSP00000265708	ENSP00000278853	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida	0.904
ADAM2	ZP2	ENSP00000265708	ENSP00000219593	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor	0.932
ADAM2	ZP3	ENSP00000265708	ENSP00000378326	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation	0.923
ADAM2	ZP4	ENSP00000265708	ENSP00000355529	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor	0.905
ADAM20	ADAM2	ENSP00000256389	ENSP00000265708	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	0.917
ADAM20	ADAM21	ENSP00000256389	ENSP00000267499	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	0.902
ADAM20	ADAM30	ENSP00000256389	ENSP00000358407	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization	0.908
ADAM20	B4GALT1	ENSP00000256389	ENSP00000369055	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.900
ADAM20	OVGP1	ENSP00000256389	ENSP00000358747	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development	0.900
ADAM20	ZP1	ENSP00000256389	ENSP00000278853	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida	0.900
ADAM20	ZP2	ENSP00000256389	ENSP00000219593	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor	0.900
ADAM20	ZP3	ENSP00000256389	ENSP00000378326	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation	0.902
ADAM20	ZP4	ENSP00000256389	ENSP00000355529	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor	0.900
ADAM21	ADAM2	ENSP00000267499	ENSP00000265708	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	0.914
ADAM21	ADAM20	ENSP00000267499	ENSP00000256389	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	0.902

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