12 items (Homo sapiens) - STRING network view

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	ZP2	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (745 aa)
	DAZL	deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3’-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity) (315 aa)
	ADAM20	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization (776 aa)
	ADAM2	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa)
	ADAM21	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients (722 aa)
	ZP1	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (638 aa)
	ZP4	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor (540 aa)
	GUK1	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP (241 aa)
	ADAM30	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization (790 aa)
	OVGP1	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development (678 aa)
	B4GALT1	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (398 aa)
	ZP3	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation (424 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM2	ADAM20	ENSP00000265708	ENSP00000256389	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	0.917
ADAM2	ADAM21	ENSP00000265708	ENSP00000267499	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	0.914
ADAM2	ADAM30	ENSP00000265708	ENSP00000358407	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization	0.908
ADAM2	B4GALT1	ENSP00000265708	ENSP00000369055	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.900
ADAM2	OVGP1	ENSP00000265708	ENSP00000358747	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development	0.904
ADAM2	ZP1	ENSP00000265708	ENSP00000278853	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida	0.904
ADAM2	ZP2	ENSP00000265708	ENSP00000219593	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor	0.932
ADAM2	ZP3	ENSP00000265708	ENSP00000378326	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation	0.923
ADAM2	ZP4	ENSP00000265708	ENSP00000355529	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor	0.905
ADAM20	ADAM2	ENSP00000256389	ENSP00000265708	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	0.917
ADAM20	ADAM21	ENSP00000256389	ENSP00000267499	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	0.902
ADAM20	ADAM30	ENSP00000256389	ENSP00000358407	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization	0.908
ADAM20	B4GALT1	ENSP00000256389	ENSP00000369055	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.900
ADAM20	OVGP1	ENSP00000256389	ENSP00000358747	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development	0.900
ADAM20	ZP1	ENSP00000256389	ENSP00000278853	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida	0.900
ADAM20	ZP2	ENSP00000256389	ENSP00000219593	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor	0.900
ADAM20	ZP3	ENSP00000256389	ENSP00000378326	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation	0.902
ADAM20	ZP4	ENSP00000256389	ENSP00000355529	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor	0.900
ADAM21	ADAM2	ENSP00000267499	ENSP00000265708	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein	0.914
ADAM21	ADAM20	ENSP00000267499	ENSP00000256389	ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients	ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization	0.902

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