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AKT1 AKT1 ZHX2 ZHX2 RAF1 RAF1 MRPS2 MRPS2 MAP2K1 MAP2K1 MRPL49 MRPL49 MRPL40 MRPL40 PEBP4 PEBP4 MRPL46 MRPL46 MRPL16 MRPL16 MRPL17 MRPL17 MRPL13 MRPL13 MRPL3 MRPL3 NUP62CL NUP62CL MRPL19 MRPL19 MRPL1 MRPL1 MRPL22 MRPL22 MRPL32 MRPL32 MRPL27 MRPL27 MRPL4 MRPL4 MRPL15 MRPL15 MRPL23 MRPL23 MRPL47 MRPL47 MRPL43 MRPL43 MRPL41 MRPL41 MRPL11 MRPL11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
RAF1v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] (648 aa)
MRPL4mitochondrial ribosomal protein L4 (311 aa)
PEBP4phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization (227 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
MRPL3mitochondrial ribosomal protein L3 (348 aa)
AKT1v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
MRPL16mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome (251 aa)
MAP2K1mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] (393 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL11mitochondrial ribosomal protein L11 (192 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
ZHX2zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA (837 aa)
MRPL1mitochondrial ribosomal protein L1 (325 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
NUP62CLnucleoporin 62kDa C-terminal like (184 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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