node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | MAP2K1 | ENSP00000270202 | ENSP00000302486 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | 0.505 |
AKT1 | PEBP4 | ENSP00000270202 | ENSP00000256404 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization | 0.667 |
AKT1 | RAF1 | ENSP00000270202 | ENSP00000251849 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.998 |
AKT1 | ZHX2 | ENSP00000270202 | ENSP00000314709 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.570 |
MAP2K1 | AKT1 | ENSP00000302486 | ENSP00000270202 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.505 |
MAP2K1 | PEBP4 | ENSP00000302486 | ENSP00000256404 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization | 0.881 |
MAP2K1 | RAF1 | ENSP00000302486 | ENSP00000251849 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.999 |
MAP2K1 | ZHX2 | ENSP00000302486 | ENSP00000314709 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.570 |
MRPL1 | MRPL11 | ENSP00000315017 | ENSP00000308897 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L11 | 0.999 |
MRPL1 | MRPL13 | ENSP00000315017 | ENSP00000306548 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L13 | 0.986 |
MRPL1 | MRPL15 | ENSP00000315017 | ENSP00000260102 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L15 | 0.968 |
MRPL1 | MRPL16 | ENSP00000315017 | ENSP00000300151 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome | 0.990 |
MRPL1 | MRPL17 | ENSP00000315017 | ENSP00000288937 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L17 | 0.971 |
MRPL1 | MRPL19 | ENSP00000315017 | ENSP00000377486 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L19 | 0.987 |
MRPL1 | MRPL22 | ENSP00000315017 | ENSP00000431040 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L22 | 0.971 |
MRPL1 | MRPL23 | ENSP00000315017 | ENSP00000370930 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L23 | 0.908 |
MRPL1 | MRPL27 | ENSP00000315017 | ENSP00000225969 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L27 | 0.948 |
MRPL1 | MRPL3 | ENSP00000315017 | ENSP00000264995 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L3 | 0.993 |
MRPL1 | MRPL32 | ENSP00000315017 | ENSP00000223324 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L32 | 0.892 |
MRPL1 | MRPL4 | ENSP00000315017 | ENSP00000253099 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L4 | 0.999 |