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STRINGSTRING
LY75 LY75 SVEP1 SVEP1 CLEC12A CLEC12A MPP7 MPP7 REG3A REG3A REG4 REG4 CLEC1B CLEC1B CLEC4G CLEC4G MPP6 MPP6 CLEC12B CLEC12B SELE SELE CLEC5A CLEC5A CLEC2D CLEC2D MPP5 MPP5 LY75-CD302 LY75-CD302 MPP4 MPP4 CLEC7A CLEC7A ADAMDEC1 ADAMDEC1 KLRB1 KLRB1 MPP2 MPP2 CD72 CD72 FCER2 FCER2 MPP3 MPP3 MPP1 MPP1 CASK CASK ACAN ACAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MPP6membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa)
KLRB1killer cell lectin-like receptor subfamily B, member 1; Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediat [...] (225 aa)
ADAMDEC1ADAM-like, decysin 1; May play an important role in the control of the immune response and during pregnancy (By similarity) (470 aa)
REG4regenerating islet-derived family, member 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (158 aa)
CD72CD72 molecule; Plays a role in B-cell proliferation and differentiation (359 aa)
CLEC2DC-type lectin domain family 2, member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans (194 aa)
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa)
FCER2Fc fragment of IgE, low affinity II, receptor for (CD23); Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) (321 aa)
MPP2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa)
CLEC1BC-type lectin domain family 1, member B; Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (229 aa)
CLEC7AC-type lectin domain family 7, member A (247 aa)
REG3Aregenerating islet-derived 3 alpha; Binds to Gram-positive bacteria and restricts their association with the small intestinal epithelial surface. Consequently, limits the activation of adaptive immune responses by the microbiota (By similarity). Mannan- and peptidoglycan- binding lectin. In vitro, may have some direct antibacterial activity against Gram-positive enteric microbes (PubMed-16931762) (175 aa)
CLEC4GC-type lectin domain family 4, member G (293 aa)
SELEselectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis (610 aa)
MPP7membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (576 aa)
CLEC12BC-type lectin domain family 12, member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (276 aa)
CLEC12AC-type lectin domain family 12, member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (275 aa)
MPP1membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa)
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
MPP3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa)
SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (3571 aa)
MPP4membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); May play a role in retinal photoreceptors development (By similarity) (637 aa)
ACANaggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
LY75-CD302LY75-CD302 readthrough (1873 aa)
CLEC5AC-type lectin domain family 5, member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release (188 aa)
LY75lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes (1873 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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